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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 441 - 446 (6page)
이용수
초록· 키워드
오류제보하기
The development of diabetic nephropathy is associated with the dysfunction of proximal tubule cells. High glucose has also been considered to play an important role in alteration of Na?/glucose cotransporter in proximal tubule cells. Ginsenosides have been used as a remedy for diabetes in Asian countries. Therefore, we examined the preventive effect of ginsenosides against high glucose-induced alteration of Na?/glucose cotransporter and its related signal pathways in the primary cultured proximal tubule cells. In present study, high glucose inhibited Na?/glucose cotransporter (α-MG uptake) in proximal tubule cells. Ginsenosides total saponin (GTS), penoxatriol (PT) and penoxadiol (PD) blocked high glucose-induced inhibition of α-MG uptake in proximal tubule cells. In addition, high glucose stimulated cAMP formation and PKC activity from cytosolic to membrane fraction. GTS, PT and PD prevented high glucose-induced stimulation of cAMP and PKC activity. Moreover, high glucose stimulated TGF-β1 secretion, which was completely blocked by the treatment of GTS, PD and PT in proximal tubule cells. In conclusion, GTS prevented high glucose-induced dysfunction of proximal tubule cells via inhibition of cAMP, PKC, and TGF-β1 signaling cascades.
목차
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Arakawa, K / 2001 / Improved diabetic syndrome in C57BL/KsJ-db/db mice by oral administration of the Na+-glucose cotransporter inhibitor T-1095 132 : 578 ~ 586
2. [학술지(정기간행물)] - Asano, T / 2004 / Glucose transporter and Na+/glucose cotransporter as molecular targets of anti-diabetic drugs 11 : 2717 ~ 2724
3. [학술지(정기간행물)] - Bradford / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding : 248 ~ 254
4. [학술지(정기간행물)] - Cho, W.C / 2006 / Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats 21 : 173 ~ 179
5. [학술지(정기간행물)] - Chung / 1982 / Characterization of primary rabbit kidney cultures that express proximal tubule functions in a hormonally defined medium : 118 ~ 126
2. [학술지(정기간행물)] - Asano, T / 2004 / Glucose transporter and Na+/glucose cotransporter as molecular targets of anti-diabetic drugs 11 : 2717 ~ 2724
3. [학술지(정기간행물)] - Bradford / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding : 248 ~ 254
4. [학술지(정기간행물)] - Cho, W.C / 2006 / Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats 21 : 173 ~ 179
5. [학술지(정기간행물)] - Chung / 1982 / Characterization of primary rabbit kidney cultures that express proximal tubule functions in a hormonally defined medium : 118 ~ 126
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UCI(KEPA) : I410-ECN-0101-2009-510-016250024