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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.3
- 수록면
- 47 - 50 (4page)
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The functional analysis of genes which concerned with epilepsy is very important for epileptogenesis as well as development of therapeutic drug. The POGO mouse showed ataxia and the pogo gene was mapped on central mouse chromosome 8. In the present study, we performed that molecular approach to the identification of a gene mutated in the POGO mouse. The results of complementation test between POGO and tottering mice definitely indicated that the POGO and tottering mice are genetically allelic. Since calcium channel α1A subunit (cacna1a) is mutated in tottering mice, expression level of cacna1a gene in POGO mice were measured by real-time PCR. Expression level of cacna1a gene in homozygous POGO mice were law compare with that of normal mouse. Results of real-time PCR agree with that of complementation test. Furthermore, we recorded electroencephalograms (EEGs) of POGO mice because tottering with a mutation at cacna1a gene show absence seizures. POGO mice exhibited 2~4 ㎐ spokeand wave discharge on cortical EEGs. Taken together, our results suggested that cacna1a gene mutation was the primary cause of seizure and ataxia in POGO mouse.
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Molecular approaches to the identification of a gene mutated in the POGO mouse
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Mapping of the pogo Gene, a New Ataxic Mutant from Korean Wild Mice, on Central Mouse Chromosome 8
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The Novel Ataxic Mutant Mouse, pogo
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A New Neurological Ataxic Mouse Model, pogo
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2001 .06
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[지상4]Heat Shock Protein 25 Expression in Pogo Mouse Cerebellum
대한체질인류학회 학술대회 연제 초록
2004 .05
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Abnormal Expression of Neuropeptide Y in the Cerebellar Purkinje Cells of the Ataxic Mutant Mice, Pogo
해부·생물인류학
2004 .06
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Cerebellar Abnormalities in the Ataxic Mutant Mouse, pogo
대한체질인류학회 학술대회 연제 초록
2001 .05
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[지상5]Topological Relationships of CRF and TH Expression in the Pogo Mouse Cerebellum
대한체질인류학회 학술대회 연제 초록
2003 .05
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ElectIon Microscopic Structures of Ataxic Mutant Mouse pogo Cerebellum
대한체질인류학회 학술대회 연제 초록
2001 .05
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[지상12]Comparision of Abnormal Tyrosine Hydroxylase Expression in the Purkinje celIs of Ataxic Mutant Mice(pogo, tottering, leaner and rolling mouse Nagoya)
대한체질인류학회 학술대회 연제 초록
2002 .05
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[지상3]Phosphorylated Tyrosine Hydroxylase Expression in the Purkinje Cells of the Pogo Mouse
대한체질인류학회 학술대회 연제 초록
2004 .05
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[지상2]Elevated Expression of the α1A Subunit of VGCC in the deep cerebellar Nucleus of the Pogo Mouse
대한체질인류학회 학술대회 연제 초록
2004 .05
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Elevated Serotonin Transporter (5-HTT) Expression in the Ventral Horn of Lumbar Spinal Cord of Ataxic Pogo Mice
Laboratory Animal Research
2008 .12
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Overexpression of hARD1235 accelerates Tumorigenesis in APCMIN/+Mice
한국실험동물학회 학술발표대회 논문집
2009 .04
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Suppression of Transglutaminase-2 is Involved in Anti-Inflammatory Actions of Glucosamine in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation
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Inflammatory Large Bowel Disease due to Helicobacter hepaticus infection in BALB/cA-Hfh11nu Mice
Laboratory Animal Research
2002 .09
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[지상3]Expressions of α1A Subunit of a Voltage-gated Ca2+ Channel in the Deep Cerebella Nucleus of Pogo Mouse Cerebellum
대한체질인류학회 학술대회 연제 초록
2003 .05
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Abnormal Expression of Tyrosine Hydroxylase in the Cerebellar Purkinje cells of the Ataxic Mutant Mouse, pogo
대한체질인류학회 학술대회 연제 초록
2001 .05
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Comparison of Ectopic Expression of Neuropeptide Y and Tyrosine Hydroxylase in the Ataxic Mutant Mice Pogo Cerebellum
한국실험동물학회 학술발표대회 논문집
2002 .06
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UCI(KEPA) : I410-ECN-0101-2009-510-019510614