지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 201 - 211 (11page)
이용수
초록· 키워드
오류제보하기
Objectives：The purpose of this study was to investigate the relationships between sexual hormone level and cognition in male patients with schizophrenia.
Methods：Total 80 male patients with schizophrenia were involved in this study. Among them, 61 patients were classified into normal cognition group(NCG) and 19 patients for lower cognition group(LCG), according to the Korean version of Consortium to Establish a Registry for Alzheimer’s Disease(CERAD-K) and Korean-Color Word Stroop Test. LCG was identified who were included at the below 5 percentile in at least one domain of the cognitive test. All the participants completed Positive and Negative Syndrome Scale(PANSS), Simpson Angus rating Scales(SAS) and Hamilton rating scale for Depression(HAM-D). Sexual hormone levels of prolactin, total testosterone, free-testosterone and estradiol were also checked by blood hormonal assays.
Results：The patients with higher total testosterone level on construction domain were more likely to be included in LCG than NCG. Statistically significant correlations were still observed after adjustment of the several covariants. Total testosterone, free testosterone and estradiol levels have statistically significant positive correlations between each other, but there were negative correlations between prolactin and other hormone levels in 80 male patients with schizophrenia.
Conclusion：These results suggest that sexual hormone may modulate the cognitive deficits in patients with chronic schizophrenia. Sexual hormone levels would be considered as predictive factors about cognitive function of patients with chronic schizophrenia. Furthermore, longitudinal and large-scale control studies would be needed to confirm these results.
Methods：Total 80 male patients with schizophrenia were involved in this study. Among them, 61 patients were classified into normal cognition group(NCG) and 19 patients for lower cognition group(LCG), according to the Korean version of Consortium to Establish a Registry for Alzheimer’s Disease(CERAD-K) and Korean-Color Word Stroop Test. LCG was identified who were included at the below 5 percentile in at least one domain of the cognitive test. All the participants completed Positive and Negative Syndrome Scale(PANSS), Simpson Angus rating Scales(SAS) and Hamilton rating scale for Depression(HAM-D). Sexual hormone levels of prolactin, total testosterone, free-testosterone and estradiol were also checked by blood hormonal assays.
Results：The patients with higher total testosterone level on construction domain were more likely to be included in LCG than NCG. Statistically significant correlations were still observed after adjustment of the several covariants. Total testosterone, free testosterone and estradiol levels have statistically significant positive correlations between each other, but there were negative correlations between prolactin and other hormone levels in 80 male patients with schizophrenia.
Conclusion：These results suggest that sexual hormone may modulate the cognitive deficits in patients with chronic schizophrenia. Sexual hormone levels would be considered as predictive factors about cognitive function of patients with chronic schizophrenia. Furthermore, longitudinal and large-scale control studies would be needed to confirm these results.
목차
서론
대상 및 방법
결과
고찰
참고문헌
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - McGrath J / 2008 / Schizophrenia: a concise overview of incidence, prevalence, and mortality / Epidemiol Rev 30 : 67 ~ 76
2. [학술지(정기간행물)] - Abel KM / 2010 / Sex differences in schizophrenia / Int Rev Psychiatry 22 : 417 ~ 428
3. [학술지(정기간행물)] - Green MF / 2014 / Cognition in schizophrenia: Past, present, and future / Schizophr Res Cogn 1 : e1 ~ e9
4. [학술지(정기간행물)] - Maat A / 2012 / Social cognition and quality of life in schizophrenia / Schizophr Res 137 : 212 ~ 218
5. [학술지(정기간행물)] - Harvey PD / 2004 / Improvement in cognitive function following a switch to ziprasidone from conventional antipsychotics, olanzapine, or risperidone in outpatients with schizophrenia / Schizophr Res 66 : 101 ~ 113
2. [학술지(정기간행물)] - Abel KM / 2010 / Sex differences in schizophrenia / Int Rev Psychiatry 22 : 417 ~ 428
3. [학술지(정기간행물)] - Green MF / 2014 / Cognition in schizophrenia: Past, present, and future / Schizophr Res Cogn 1 : e1 ~ e9
4. [학술지(정기간행물)] - Maat A / 2012 / Social cognition and quality of life in schizophrenia / Schizophr Res 137 : 212 ~ 218
5. [학술지(정기간행물)] - Harvey PD / 2004 / Improvement in cognitive function following a switch to ziprasidone from conventional antipsychotics, olanzapine, or risperidone in outpatients with schizophrenia / Schizophr Res 66 : 101 ~ 113
이 논문의 저자 정보
이 논문과 함께 이용한 논문
조현병 환자에서 정신병리와 인지 기능과의 연관성
김성진
,
심주철
,
공보금
외 7명
생물치료정신의학
2013
.10
상동행동에 대한 정신의학적 접근법
서민재
,
김기홍
생물치료정신의학
2015
.06
조현병 환자의 인지기능 및 심리사회적 요인과 직업재활과의 연관성
김현정
,
김성진
,
공보금
외 7명
생물치료정신의학
2014
.08
스트레스관리 프로그램이 조현병 환자의 스트레스 지각, 대처방식, 자아존중감에 미치는 효과
양승희
,
전경선
스트레스硏究
2015
.12
당뇨병을 가진 노인에서의 혈압과 인지기능 사이의 관련성
이소영
,
박철수
,
이철순
외 6명
생물치료정신의학
2015
.06
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-513-001023806