지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.6
- 수록면
- 84 - 89 (6page)
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The main stream of CD137 studies has been directed to the function of CD137 in CD8<sup>+</sup> T-cell immunity, including its anti-tumor activity, and paradoxically the immunosuppressive activity of CD137, which proves to be of a great therapeutic potential for animal models of a variety of autoimmune and inflammatory diseases. Recent studies, however, add complexes to the biology of CD137. Accumulating is evidence supporting that there exists a bidirectional signal transduction pathway for the CD137 receptor and its ligand (CD137L). CD137/CD137L interactions are involved in the network of hematopoietic and nonhematopoietic cells in addition to the well characterized antigen-presenting cell-T cell interactions. Signaling through CD137L plays a critical role in the differentiation of myeloid cells and their cellular activities, suggesting that CD137L signals trigger and sustain inflammation. The overall consequence might be that the amplified inflammation by CD137L enhances the T-cell activity together with CD137 signals by upregulating costimulatory molecules, MHC molecules, cell adhesion molecules, cytokines, and chemokines. Solving this outstanding issue is urgent and will have an important clinical implication.
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참고문헌 (51)
참고문헌 신청
1. [학술지(정기간행물)] - Kwon B / 2000 / 4-1BB: still in the midst of darkness / Mol Cells 10 : 119 ~ 126
2. [학술지(정기간행물)] - Kwon B / 2002 / New insights into the role of 4-1BB in immune responses: beyond CD8+ T cells / Trends Immunol 23 : 378 ~ 380
3. [학술지(정기간행물)] - Croft M / 2009 / The role of TNF superfamily members in T-cell function and diseases / Nat Rev Immunol 9 : 271 ~ 285
4. [학술지(정기간행물)] - Shuford WW / 1997 / 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses / J Exp Med 186 : 47 ~ 55
5. [학술지(정기간행물)] - Takahashi C / 1999 / Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal / J Immunol 162 : 5037 ~ 5040
2. [학술지(정기간행물)] - Kwon B / 2002 / New insights into the role of 4-1BB in immune responses: beyond CD8+ T cells / Trends Immunol 23 : 378 ~ 380
3. [학술지(정기간행물)] - Croft M / 2009 / The role of TNF superfamily members in T-cell function and diseases / Nat Rev Immunol 9 : 271 ~ 285
4. [학술지(정기간행물)] - Shuford WW / 1997 / 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses / J Exp Med 186 : 47 ~ 55
5. [학술지(정기간행물)] - Takahashi C / 1999 / Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal / J Immunol 162 : 5037 ~ 5040
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