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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.8
- 수록면
- 241 - 246 (6page)
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초록· 키워드
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Purpose: Aloe-emodin (AE), an ingredient of aloe, is known to exhibit anti-inflammatory activities. However, little is known about the underlying molecular mechanisms of its inflammatory modulatory activity in vitro. In the present study, we investigated the anti-inflammatory potential of AE using Pam₃CSK₄-stimulated macrophages. Methods: RAW 264.7 macrophages were treated with AE (0~20 mM) for 1 h, followed by treatment with Pam3CSK4 for 1 h. After incubation, mRNA expression levels of cytokines were measured. The effect of AE on TLR2-related molecules was also investigated in Pam₃CSK₄-stimulated RAW 264.7 macrophages. Results: AE attenuated Pam₃CSK₄-stimulated expression of proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in RAW 264.7 macrophages. Two concentrations of AE (10 μM and 20 μM) effectively reduced mRNA expression of TLR2 by 41.18% and 54.43%, respectively, compared to that in control cells (p < 0.05). AE also decreased nuclear factor-kappa B (NF-κB) activation and mitogen-activated protein kinase (MAPK) phosphorylation. Phosphorylation levels of ERK1/2, p38, and JNK were markedly reduced by 20 μM AE. In particular, AE decreased phosphorylation of ERK in a dose-dependent manner in Pam₃CSK₄-stimulated RAW 264.7 macrophages. Conclusion: Our data indicate that AE exerts its anti-inflammatory effect by suppressing TLR2-mediated activation of NF-κB and MAPK signaling pathways in macrophages.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
SUMMARY
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Farzadinia P / 2016 / Anti-inflammatory and wound healing activities of aloe vera, honey and milk ointment on seconddegree burns in rats / Int J Low Extrem Wounds 15 (3) : 241 ~ 247
[학술지(정기간행물)] - Al-Oqail MM / 2016 / In vitro anti-proliferative activities of Aloe perryi flowers extract on human liver, colon, breast, lung, prostate and epithelial cancer cell lines / Pak J Pharm Sci 29 (2 Suppl) : 723 ~ 729
[학술지(정기간행물)] - Park MY / 2011 / Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model / Life Sci 88 (11-12) : 486 ~ 492
[학술지(정기간행물)] - Andersen DO / 1991 / In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives / Antiviral Res 16 (2) : 185 ~ 196
[학술지(정기간행물)] - Arosio B / 2000 / Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride / Pharmacol Toxicol 87 (5) : 229 ~ 233
[학술지(정기간행물)] - Al-Oqail MM / 2016 / In vitro anti-proliferative activities of Aloe perryi flowers extract on human liver, colon, breast, lung, prostate and epithelial cancer cell lines / Pak J Pharm Sci 29 (2 Suppl) : 723 ~ 729
[학술지(정기간행물)] - Park MY / 2011 / Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model / Life Sci 88 (11-12) : 486 ~ 492
[학술지(정기간행물)] - Andersen DO / 1991 / In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives / Antiviral Res 16 (2) : 185 ~ 196
[학술지(정기간행물)] - Arosio B / 2000 / Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride / Pharmacol Toxicol 87 (5) : 229 ~ 233
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UCI(KEPA) : I410-ECN-0101-2017-594-001146341