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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 327 - 335 (9page)
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This study aimed to evaluate the potential toxicity and safety of ethyl hydrogen adipate (EHA) by determining its effect on the reproductive function and development of Sprague-Dawley (SD) rats at dose levels of 0 (control), 200, 400, and 800 mg/kg/day. One male and five females of the 800 mg/kg/day died. Body weight loss was observed in the males of the 800 mg/kg/day and in females of the 400 and 800 mg/kg/day. In addition, mating indices decreased and pre-implantation loss rates increased in parental animals of the 400 and 800 mg/kg/day. The gestation index decreased in the male and female rats of the 800 mg/kg/day. Moreover, the body weight of the pups from the 800 mg/kg/day group decreased on post-parturition day 4. These results indicated that the no-observed-adverse-effect level of EHA for parental males and females was 400 mg/kg/day and 200 mg/kg/day, respectively, and that for pups was 400 mg/kg/day.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (9)
참고문헌 신청
LookChem / Monoethyl Adipate
OECD Existing Chemical Database / Ethyl hydrogen adipate
OECD / 1995 / OECD Test Guideline for Testing Chemicals, No. 421, Reproduction/Developmental Toxicity Screening Test / Adopted by the Council on 27th
OECD / 1998 / OECD Principles on Good Laboratory Practice (as revised in 1997) / OECD Series on Good Laboratory Practice and Compliance Monitoring, No. 1
ChemIDPlus (A Toxnet Database). / Adipic acid monoethyl ester
OECD Existing Chemical Database / Ethyl hydrogen adipate
OECD / 1995 / OECD Test Guideline for Testing Chemicals, No. 421, Reproduction/Developmental Toxicity Screening Test / Adopted by the Council on 27th
OECD / 1998 / OECD Principles on Good Laboratory Practice (as revised in 1997) / OECD Series on Good Laboratory Practice and Compliance Monitoring, No. 1
ChemIDPlus (A Toxnet Database). / Adipic acid monoethyl ester
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UCI(KEPA) : I410-ECN-0101-2017-513-001339592