메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색
질문

논문 기본 정보

자료유형
학술저널
저자정보
Hyeon-Joong Kim (Konkuk University) Seok-Won Jung (Konkuk University) Seog-Young Kim (University of Ulsan College of Medicine and Institute of Life Science, Asan Medical Center) Ik-Hyun Cho (Kyung Hee University) Hyoung-Chun Kim (Kangwon National University) Hyewhon Rhim (Korea Institute of Science and Technology) Manho Kim (Seoul National University Hospital) Seung-Yeol Nah (Konkuk University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.42 No.4
발행연도
2018.10
수록면
401 - 411 (11page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색
질문

초록· 키워드

오류제보하기
Longevity in medicine can be defined as a long life without mental or physical deficits. This can be prevented by Alzheimer’s disease (AD). Current conventional AD treatments only alleviate the symptoms without reversing AD progression. Recent studies demonstrated that Panax ginseng extract improves AD symptoms in patients with AD, and the two main components of ginseng might contribute to AD amelioration. Ginsenosides show various AD-related neuroprotective effects. Gintonin is a newly identified ginseng constituent that contains lysophosphatidic acids and attenuates AD-related brain neuropathies. Ginsenosides decrease amyloid β-protein (Aβ) formation by inhibiting β- and γ-secretase activity or by activating the nonamyloidogenic pathway, inhibit acetylcholinesterase activity and Abinduced neurotoxicity, and decrease Aβ-induced production of reactive oxygen species and neuroinflammatory reactions. Oral administration of ginsenosides increases the expression levels of enzymes involved in acetylcholine synthesis in the brain and alleviates Aβ-induced cholinergic deficits in AD models. Similarly, gintonin inhibits Aβ-induced neurotoxicity and activates the nonamyloidogenic pathway to reduce Aβ formation and to increase acetylcholine and choline acetyltransferase expression in the brain through lysophosphatidic acid receptors. Oral administration of gintonin attenuates brain amyloid plaque deposits, boosting hippocampal cholinergic systems and neurogenesis, thereby ameliorating learning and memory impairments. It also improves cognitive functions in patients with AD. Ginsenosides and gintonin attenuate AD-related neuropathology through multiple routes. This review focuses research demonstrating that ginseng constituents could be a candidate as an adjuvant for AD treatment. However, clinical investigations including efficacy and tolerability analyses may be necessary for the clinical acceptance of ginseng components in combination with conventional AD drugs.
#Adjuvant #Alzheimer's disease #Ginsenoside #Gintonin #Panax ginseng

목차

abstract
1. Introduction
2. Effects of ginseng extract on animal models of and patients with AD
3. Effects of ginseng components on Ab formation
4. Effects of ginseng components on the brain’s cholinergic systems
6. Effects of ginseng components on Aβ-induced neuroinflammation
5. Effects of ginseng components on Aβ-induced reactive oxidative stress
7. Effects of ginseng components on hippocampal neurogenesis
8. Gintonin improves impaired cognitive functions in elderly AD dementia
9. Perspective and conclusion
References

참고문헌 (82)

참고문헌 신청
[학술지(정기간행물)] - Burns A / 2009 / Alzheimer's disease / BMJ 338 : b158 ~ google schola [학술지(정기간행물)] - Querfurth HW / 2010 / Alzheimer's disease / N Engl J Med 362 : 329 ~ 344 google schola [학술지(정기간행물)] - Hardy J / 1991 / Amyloid deposition as the central event in the aetiology of Alzheimer's disease / Trends Pharmacol Sci 12 : 383 ~ 388 google schola [학술지(정기간행물)] - Hollands C / 2016 / Alzheimer's disease and hippocampal adult neurogenesis; exploring shared mechanisms / Front Neurosci 10 : 178 ~ google schola [학술지(정기간행물)] - Mudher A / 2002 / Alzheimer's disease-do tauists and baptists finally shake hands? / Trends Neurosci 25 : 22 ~ 26 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0