지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 713 - 718 (6page)
이용수
초록· 키워드
오류제보하기
In this study, the effects of sitagliptin analogue (SITA) or pioglitazone (PIO) treatment on glucose homeostasis and β-cell dynamics in animal models of type 2 diabetes--Akita and db/db mice were evaluated. After 4-6 weeks of treatment, both SITA and PIO were shown to lower non-fasting glucose levels and reduced glycemic excursion in the intraperitoneal glucose tolerance test. In addition, both drugs preserved normal islet structure and the proportion of β-cells in the islets. Compared to the controls, SITA treatment induced a higher β-cell proliferation rate in Akita mice and a lower rate of apoptosis in db/db mice,whereas PIO treatment induced a lower rate of apoptosis in db/db mice and reduced proliferation rates in Akita mice. In conclusion, both SITA and PIO appear to exert some beneficial effects on the islet structure in addition to glycemic control via different mechanisms that involve β-cell dynamics in Akita and db/db mice. [BMB reports 2011; 44(11): 713-718]
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Bergman, R. N / 1981 / Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the r
Butler, A. E / 2003 / Beta-cell deficit and increased beta- cell apoptosis in humans with type 2 diabetes / Diabetes 52 : 102 ~ 110
Campbell, I. W / 2007 / Beta-cell preservation with thiazolidinediones / Diabetes Res. Clin. Pract 76 : 163 ~ 176
Chen, H / 1996 / Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice / Cell 84 : 491 ~ 495
Drucker, D. J / 2006 / The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase- 4 inhibitors in type 2 diabetes / Lancet 368 : 1696 ~ 1705
Butler, A. E / 2003 / Beta-cell deficit and increased beta- cell apoptosis in humans with type 2 diabetes / Diabetes 52 : 102 ~ 110
Campbell, I. W / 2007 / Beta-cell preservation with thiazolidinediones / Diabetes Res. Clin. Pract 76 : 163 ~ 176
Chen, H / 1996 / Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice / Cell 84 : 491 ~ 495
Drucker, D. J / 2006 / The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase- 4 inhibitors in type 2 diabetes / Lancet 368 : 1696 ~ 1705
이 논문의 저자 정보
최근 본 자료
댓글(0)
0