지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 383 - 389 (7page)
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Background: Hemoglobin A1c (HbA1c) was adopted as a new standard criterion for diagnosing diabetes. We investigated the diagnostic utility of HbA1c by comparing the 2003 American Diabetes Association (ADA) diagnostic criteria of diabetes with HbA1c of 6.5%. Furthermore, the cut-off value for HbA1c was investigated using receiver operating characteristic curves.
Methods: This study included 224 subjects without a history of diabetes that had a fasting plasma glucose level of above 100 mg/dL. The subjects had undergone a 75 g oral glucose tolerance test, and diabetes was defi ned as according to 2003ADA criteria.
Results: The prevalence of newly diagnosed diabetes was 58.2% by the 2003 ADA criteria, and 47.8% by HbA1c of 6.5%,which underestimated the prevalence of diabetes. Compared with the 2003 ADA criteria, the sensitivity and specifi city of HbA1c of 6.5% were 73.5% and 89.1%, respectively. The kappa index of agreement between 2003 ADA and HbA1c criteria was 0.60. The cut-off point of HbA1c for diagnosing diabetes was 6.45% (sensitivity, 73.3%; specifi city, 88.2%; area under the curve, 0.85). HbA1c was signifi cantly associated with fasting glucose (r = 0.82, P < 0.01), postprandial glucose (r = 0.78,P < 0.01), and homeostasis model assessment of insulin resistance (r = 0.16, P < 0.05).
Conclusion: For high risk patients whose fasting glucose was more than 100 mg/dL, HbA1c criterion underestimated the prevalence of newly diagnosed diabetes compared to the 2003 ADA criteria, and showed moderate agreement. The cutoff value for HbA1c was 6.45%, which was similar to the recommended diagnostic criterion of HbA1c by the 2009 ADA.
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참고문헌 (29)
참고문헌 신청
Carson AP / 2010 / Comparison of A1C and fasting glucose criteria to diagnose diabetes among U.S. adults / Diabetes Care 33:95~97
Osei K / 2003 / Is glycosylated hemoglobin A1c a surrogate for metabolic syndrome in nondiabetic, first-degree relatives of African-American patients with type 2 diabetes / J Clin Endocrinol Metab 88:4596~4601
de Vegt F / 1999 / Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn Study / Diabetologia 42:926~931
Lorenzo C / 2010 / A1C between 5.7 and 6.4% as a marker for identifying pre-diabetes, insulin sensitivity and secretion, and cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study (IRA S) / Diabetes Care 33:2104~2109
Dilley J / 2007 / Association of A1C with cardiovascular disease and metabolic syndrome in Asian Indians with normal glucose tolerance / Diabetes Care 30:1527~1532
Osei K / 2003 / Is glycosylated hemoglobin A1c a surrogate for metabolic syndrome in nondiabetic, first-degree relatives of African-American patients with type 2 diabetes / J Clin Endocrinol Metab 88:4596~4601
de Vegt F / 1999 / Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn Study / Diabetologia 42:926~931
Lorenzo C / 2010 / A1C between 5.7 and 6.4% as a marker for identifying pre-diabetes, insulin sensitivity and secretion, and cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study (IRA S) / Diabetes Care 33:2104~2109
Dilley J / 2007 / Association of A1C with cardiovascular disease and metabolic syndrome in Asian Indians with normal glucose tolerance / Diabetes Care 30:1527~1532
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