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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 650 - 657 (8page)
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Purpose The purpose of this study is to report on the incidence and the experience in management of radiation-induced sarcoma (RIS) at a large single center in Korea for 15 years.
Materials and Methods We retrospectively reviewed the sarcoma registry of a large institution from January 2000 to April 2014.
Results Out of the 3,674 patients listed in the registry, 33 patients (0.9%) diagnosed with RIS were identified. The median latency of RIS was 12.1 years. The number of cases of RIS increased from four cases in the years 2000-2003 to 14 cases in the years 2012-2014. The most common histology was osteosarcoma (36.4%). The median follow-up period was 23.1 months, the median overall survival (OS) of all patients was 2.9 years, and their 5-year survival rate was 44.7%. Univariate and multivariate analyses showed association of the age at diagnosis (p=0.01) and the treatment aim (p=0.001) with the OS. The median OS and the 5-year survival rate of patients treated with curative surgery (n=19) were 9.6 years and 65%, respectively, and of the conservatively treated patients, 0.7 years and 0% (n=14).
Re-irradiation was delivered to nine patients, and radiation toxicity was observed in five patients.
Conclusion In this study, RIS accounted for 0.9% of the cases of sarcoma, with increasing incidence.
Despite the association of curative resection with increased survival, it could be applied to only 58% of the patients. Considering the limited treatment options for RIS, conduct of a genetic study to identify the underlying mechanism of RIS is needed.
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참고문헌 (24)
참고문헌 신청
Kadouri L / 2013 / Genetic predisposition to radiation induced sarcoma : possible role for BRCA and p53 mutations / Breast Cancer Res Treat 140:207~211
Mark RJ / 1994 / Postirradiation sarcomas : a single-institution study and review of the literature / Cancer 73:2653~2662
Gladdy RA / 2010 / Do radiation-associated soft tissue sarcomas have the same prognosis as sporadic soft tissue sarcomas? / J Clin Oncol 28:2064~2069
Lagrange JL / 2000 / Sarcoma after radiation therapy: retrospective multiinstitutional study of 80 histologically confirmed cases. Radiation Therapist and Pathologist Groups of the Federation Nationale des Centres de Lutte Contre le Cancer / Radiology 216:197~205
Bjerkehagen B / 2012 / Why do patients with radiation-induced sarcomas have a poor sarcoma-related survival? / Br J Cancer 106:297~306
Mark RJ / 1994 / Postirradiation sarcomas : a single-institution study and review of the literature / Cancer 73:2653~2662
Gladdy RA / 2010 / Do radiation-associated soft tissue sarcomas have the same prognosis as sporadic soft tissue sarcomas? / J Clin Oncol 28:2064~2069
Lagrange JL / 2000 / Sarcoma after radiation therapy: retrospective multiinstitutional study of 80 histologically confirmed cases. Radiation Therapist and Pathologist Groups of the Federation Nationale des Centres de Lutte Contre le Cancer / Radiology 216:197~205
Bjerkehagen B / 2012 / Why do patients with radiation-induced sarcomas have a poor sarcoma-related survival? / Br J Cancer 106:297~306
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