지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 312 - 318 (7page)
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초록· 키워드
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Purpose: Metformin can reduce diabetes-related complications and mortality. However, its use is limited because of potential lactic acidosis-associated adverse effects, particularly in renal impairment patients. We aimed to investigate the association of metformin use with lactic acidosis and hyperlactatemia in patients with type 2 diabetes.
Materials and Methods: This was a cross-sectional study from a tertiary university-affiliated medical center. A total of 1954 type 2 diabetes patients were recruited in 2007–2011, and stratified according to the estimated glomerular filtration rate of 60 mL/min/1.73 m2. Lactic acidosis was defined as plasma lactate levels >5 mmol/L and arterial pH <7.35.
Results: Metformin was used in 61.4% of the patients with type 2 diabetes mellitus. Plasma lactate levels were not different in the patients with and without metformin use. There was no difference in prevalence of hyperlactatemia and lactic acidosis between the patients with and without metformin use (18.9% vs. 18.7%, p=0.905 for hyperlactatemia and 2.8% vs. 3.3%, p=0.544 for lactic acidosis). Similar results were observed in the patients with estimated glomerular filtration rate <60 mL/min/1.73 m2. Most patientswith lactic acidosis had at least one condition related to hypoxia or poor tissue perfusion. Multiple regression analysis indicatedno association between metformin use and lactic acidosis, whereas tissue hypoxia was an independent risk factor for lactic acidosis [odds ratio 4.603 (95% confidence interval, 1.327–15.965)].
Conclusion: Metformin use was not associated with hyperlactatemia or lactic acidosis in patients with type 2 diabetes.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bailey CJ / 1996 / Metformin / N Engl J Med 334 : 574 ~ 579
Bergman U / 1978 / Epidemiology of adverse drug reactions to phenformin and metformin / Br Med J 2 : 464 ~ 466
Bodmer M / 2008 / Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis / Diabetes Care 31 :
Cusi K / 1996 / Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus / J Clin Endocrinol Metab 81 : 4059 ~ 4067
DeFronzo RA / 1995 / Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group / N Engl J Med 333 : 541 ~ 549
Bergman U / 1978 / Epidemiology of adverse drug reactions to phenformin and metformin / Br Med J 2 : 464 ~ 466
Bodmer M / 2008 / Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis / Diabetes Care 31 :
Cusi K / 1996 / Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus / J Clin Endocrinol Metab 81 : 4059 ~ 4067
DeFronzo RA / 1995 / Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group / N Engl J Med 333 : 541 ~ 549
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