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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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Histone modifications are key epigenetic regulatory features that have important roles in many cellular events. Lysine methylations mark various sites on the tail and globular domains of histones and their levels are precisely balanced by the action of methyltransferases (‘writers’) and demethylases (‘erasers’). In addition, distinct effector proteins (‘readers’) recognize specific methyl-lysines in a manner that depends on the neighboring amino-acid sequence and methylation state. Misregulation of histone lysine methylation has been implicated in several cancers and developmental defects. Therefore, histone lysine methylation has been considered a potential therapeutic target, and clinical trials of several inhibitors of this process have shown promising results. A more detailed understanding of histone lysine methylation is necessary for elucidating complex biological processes and, ultimately, for developing and improving disease treatments. This review summarizes enzymes responsible for histone lysine methylation and demethylation and how histone lysine methylation contributes to various biological processes.
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참고문헌 (26)
참고문헌 신청
Allfrey VG / 1964 / Structural modifications of histones and their possible role in the regulation of RNA synthesis / Science 144 : 559 ~
Allis CD / 2016 / The molecular hallmarks of epigenetic control / Nat Rev Genet 17 : 487 ~ 500
Black JC / 2012 / Histone lysine methylation dynamics: establishment, regulation, and biological impact / Mol Cell 48 : 491 ~ 507
Briggs SD / 2001 / Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae / Genes Dev 15 : 3286 ~ 32
Chandrasekharan MB / 2010 / Histone H2B ubiquitination and beyond: regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation / Epigenetics
Allis CD / 2016 / The molecular hallmarks of epigenetic control / Nat Rev Genet 17 : 487 ~ 500
Black JC / 2012 / Histone lysine methylation dynamics: establishment, regulation, and biological impact / Mol Cell 48 : 491 ~ 507
Briggs SD / 2001 / Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae / Genes Dev 15 : 3286 ~ 32
Chandrasekharan MB / 2010 / Histone H2B ubiquitination and beyond: regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation / Epigenetics
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Epigenetic regulation and chromatin remodeling in learning and memory
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Histone tail cleavage as a novel epigenetic regulatory mechanism for gene expression
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Effect of Concentrations of Cell and Substrate on Cadaverine Production from L-Lysine
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