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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 11 (11page)
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Little is known about the effects of chronic alcohol intake on the outcome of acute kidney injury (AKI). Hence, we examined the effects of chronic alcohol intake on the development of renal fibrosis following AKI in an animal model of bilateral renal ischemia–reperfusion (IR) injury. We first found that chronic alcohol exposure exacerbated bilateral IR-induced renal fibrosis and renal function impairment. This phenomenon was associated with increased bilateral IR-induced extracellular matrix deposition and an increased myofibroblast population as well as increased bilateral IR-induced expression of fibrosis-related genes in the kidneys. To explore the mechanisms underlying this phenomenon, we showed that chronic alcohol exposure enhanced β-arrestin 2 (Arrb2) expression and Akt and glycogen synthase kinase-3 (GSK3)β activation in the kidneys. Importantly, pharmacological GSK3 inhibition alleviated bilateral IR-induced renal fibrosis and renal function impairment. Furthermore, we demonstrated that Arrb2− / − mice exhibited resistance to IR-induced renal fibrosis and renal function impairment following chronic alcohol exposure, and these effects were associated with attenuated GSK3β activation in the kidneys. Taken together, our results suggest that chronic alcohol exposure may potentiate AKI via β-arrestin 2/Akt/GSK3β-mediated signaling in the kidney.
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참고문헌 (25)
참고문헌 신청
Arroyo V / 2002 / Hepatorenal syndrome in cirrhosis : pathogenesis and treatment / Gastroenterology 122 : 1658 ~ 1676
Ascon M / 2009 / Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes / Kidney Int 75 : 526 ~ 535
Basile DP / 2001 / Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function / Am J Physiol Renal Physiol 281 : F887 ~ F
Bellomo R / 2004 / Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conf
Bonventre JV / 2011 / Cellular pathophysiology of ischemic acute kidney injury / J Clin Invest 121 : 4210 ~ 4221
Ascon M / 2009 / Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes / Kidney Int 75 : 526 ~ 535
Basile DP / 2001 / Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function / Am J Physiol Renal Physiol 281 : F887 ~ F
Bellomo R / 2004 / Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conf
Bonventre JV / 2011 / Cellular pathophysiology of ischemic acute kidney injury / J Clin Invest 121 : 4210 ~ 4221
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