지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1 - 13 (13page)
이용수
초록· 키워드
오류제보하기
We found that non-small-cell lung cancer (NSCLC) cells express high levels of multiple aldehyde dehydrogenase (ALDH) isoforms via an informatics analysis of metabolic enzymes in NSCLC and immunohistochemical staining of NSCLC clinical tumor samples.
Using a multiple reaction-monitoring mass spectrometry analysis, we found that multiple ALDH isozymes were generally abundant in NSCLC cells compared with their levels in normal IMR-90 human lung cells. As a result of the catalytic reaction mediated by ALDH, NADH is produced as a by-product from the conversion of aldehyde to carboxylic acid. We hypothesized that the NADH produced by ALDH may be a reliable energy source for ATP production in NSCLC. This study revealed that NADH production by ALDH contributes significantly to ATP production in NSCLC. Furthermore, gossypol, a pan-ALDH inhibitor, markedly reduced the level of ATP. Gossypol combined with phenformin synergistically reduced the ATP levels, which efficiently induced cell death following cell cycle arrest.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Engineering an Aldehyde Dehydrogenase with respect to its substrates for Advanced 3-Hydroxypropionic acid Production
한국생물공학회 학술대회
2017 .10
-
Efficient 3-hydroxypropionic Acid Production by Biosensor-based Evolutionary Engineering of Aldehyde Dehydrogenase
한국생물공학회 학술대회
2021 .10
-
Signal Transducer and Activator of Transcription 4-Induced Up-Regulated LINC01278 Enhances Proliferation and Invasion of Non-Small Cell Lung Cancer Cells via the MicroRNA-877-5p/Activating Transcription Factor 4 Axis
조직공학과 재생의학
2024 .06
-
Crizotinib attenuates cancer metastasis by inhibiting TGFβ signaling in non-small cell lung cancer cells
Experimental and Molecular Medicine
2022 .08
-
Directed Evolution of Aldehyde Dehydrogenase for 3-Hydroxypropionic Acid Production Using Synthetic High-throughput Selection Device
한국생물공학회 학술대회
2021 .04
-
발효 전후 구기자열매 추출물의 ADH 및 ALDH 활성인자 분리 및 특성
KSBB Journal
2016 .06
-
A novel PPAR? ligand, PPZ023, overcomes radioresistance via ER stress and cell death in human non-small-cell lung cancer cells
Experimental and Molecular Medicine
2020 .10
-
miR-638 is a new biomarker for outcome prediction of non-small cell lung cancer patients receiving chemotherapy
Experimental and Molecular Medicine
2015 .01
-
Aldehyde Treatment Using Aldehyde Dehydrogenase from Egg White
한국생물공학회 학술대회
2015 .10
-
ETCS Level 1 ATP시스템에서의 선로변 중복설비 최적화 방안
제어로봇시스템학회 국내학술대회 논문집
2018 .05
-
바이오-전기화학 융합기술 기반 NADH 재생 시스템 연구
공학기술논문지
2024 .09
-
Evaluation of Aldehyde Reduction Activity Using Cytosolic Extract from Aldehyde Dehydrogenase 6 Overexpressed Yeasts
한국생물공학회 학술대회
2016 .04
-
약용식물 추출물을 포함한 혼합 복합물의 혈중 알코올 농도와 숙취 해소 효과
Journal of Chitin and Chitosan
2019 .01
-
Coordinated Reprogramming of ATP Metabolism Strongly Enhances Adipic Acid Production in Escherichia coli
한국생물공학회 학술대회
2024 .09
-
The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer
Experimental and Molecular Medicine
2020 .01
-
열차제어시스템 ATP 모듈화에 따른 가상 디바이스 인터페이스 설계
한국철도학회 학술발표대회논문집
2016 .10
-
Engineering of Alcohol/Aldehyde Dehydrogenase-Based Whole-Cell Biocatalysts for Biosynthesis of C9 to C12 Dicarboxylic Acids
한국생물공학회 학술대회
2019 .04
-
먹는물의 미생물 실시간 감시를 위한 온라인 ATP 측정법의 적용
한국수처리학회지
2021 .10
-
Light-up Aptamer Amplification Assay for Quantification of ATP
한국생물공학회 학술대회
2021 .10
-
DNA methylome and single-cell transcriptome analyses reveal CDA as a potential druggable target for ALK inhibitor–resistant lung cancer therapy
Experimental and Molecular Medicine
2022 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0