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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 385 - 390 (6page)
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초록· 키워드
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Objective The purpose of this study is to investigate the incidence of lymph node metastasis in early endometrial cancer patientsand to evaluate preoperative clinicopathological factors predicting lymph node metastasis.
Methods We identified 142 patients with endometrial cancer between January 2000 and February 2013. All patientsdemonstrated endometrioid adenocarcinoma with grade 1 or 2 on preoperative endometrial biopsy. Preoperativemagnetic resonance imaging showed that tumors were confined to the uterine corpus with superficial myometrialinvasion (less than 50%), and there were no lymph nodes enlargements. All patients had complete staging proceduresand were surgically staged according to the 2009 FIGO (International Federation of Gynecology and Obstetrics) stagingsystem. Clinical and pathological data were obtained from medical records and statistically analyzed.
Results Of the 142 patients, 127 patients (89.4%) presented with stage 1A, 8 (5.6%) with stage IB, 3 (2.1%) with stage II, and4 (2.8%) with stage III disease. Three patients (2.1%) had lymph node metastasis—2 IIIC1 and 1 IIIC2 disease. Age,preoperative tumor grade, and myometrial invasion less than 50% on preoperative MRI were not associated withlymph node metastasis. A high preoperative serum CA-125 level (>35 IU/mL) was a statistically significant factor forpredicting lymph node metastasis on univariate and multivariate analyses. Lymph node metastasis was only found inpatients with preoperative grade 2 tumors or a high serum CA-125 level.
Conclusion Preoperative tumor grade and serum CA-125 level can predict lymph node metastasis in apparent early endometrialcancer patients.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
ASTEC study group. / 2009 / Efficacy of systematic pelvic lymphadenectomy in endometrial cancer(MRC ASTEC trial) : a randomised study / Lancet 373 : 125 ~ 136
AlHilli MM. / 2013 / The role of para-aortic lymphadenectomy in endometrial cancer / Int J Clin Oncol 18 : 193 ~ 199
American College of Obstetricians and Gynecologists. / 2005 / ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005 :
Benedetti Panici P. / 2008 / Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma : randomized clinical trial / J Natl Cancer Inst 10
Chao A. / 2013 / Potential of an age-stratified CA125 cut-off value to improve the prognostic classification of patients with endometrial cancer / Gynecol Oncol 129 : 500 ~
AlHilli MM. / 2013 / The role of para-aortic lymphadenectomy in endometrial cancer / Int J Clin Oncol 18 : 193 ~ 199
American College of Obstetricians and Gynecologists. / 2005 / ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005 :
Benedetti Panici P. / 2008 / Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma : randomized clinical trial / J Natl Cancer Inst 10
Chao A. / 2013 / Potential of an age-stratified CA125 cut-off value to improve the prognostic classification of patients with endometrial cancer / Gynecol Oncol 129 : 500 ~
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