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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 301 - 314 (14page)
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초록· 키워드
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Purpose: Peritoneal carcinomatosis in gastric cancer (GC) patients results in extremelypoor prognosis. Malignant ascites samples are the most appropriate biological material touse to evaluate biomarkers for peritoneal carcinomatosis. This study identified exosomalMicroRNAs (miRNAs) differently expressed between benign liver cirrhosis-associated ascites(LC-ascites) and malignant gastric cancer-associated ascites (GC-ascites), and validated theirrole as diagnostic biomarkers for GC-ascites. Materials and Methods: Total RNA was extracted from exosomes isolated from 165 ascitessamples (73 LC-ascites and 92 GC-ascites). Initially, microarrays were used to screen theexpression levels of 2,006 miRNAs in the discovery cohort (n=22). Subsequently, quantitativereverse transcriptase-polymerase chain reaction (qRT-PCR) analyses were performed tovalidate the expression levels of selected exosomal miRNAs in the training (n=70) andvalidation (n=73) cohorts. Furthermore, carcinoembryonic antigen (CEA) levels weredetermined in ascites samples. Results: The miR-574-3p, miR-181b-5p, miR-4481, and miR-181d were significantlydownregulated in the GC-ascites samples compared to the LC-ascites samples, and miR-181b-5p showed the best diagnostic performance for GC-ascites (area under the curve[AUC]=0.798 and 0.846 for the training and validation cohorts, respectively). The diagnosticperformance of CEA for GC-ascites was improved by the combined analysis of miR-181b-5pand CEA (AUC=0.981 and 0.946 for the training and validation cohorts, respectively). Conclusions: We identified exosomal miRNAs capable of distinguishing between non-malignant and GC-ascites, showing that the combined use of miR-181b-5p and CEA couldimprove diagnosis.
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참고문헌 (38)
참고문헌 신청
Leiting JL / 2018 / Optimizing outcomes for patients with gastric cancer peritoneal carcinomatosis / World J Gastrointest Oncol 10:282~289
Thomassen I / 2014 / Peritoneal carcinomatosis of gastric origin: a population-based study on incidence, survival and risk factors / Int J Cancer 134:622~628
Maeda H / 2015 / Evaluation and treatment of malignant ascites secondary to gastric cancer / World J Gastroenterol 21:10936~10947
Bartel DP / 2009 / MicroRNAs: target recognition and regulatory functions / Cell 136:215~233
Lin S / 2015 / MicroRNA biogenesis pathways in cancer / Nat Rev Cancer 15:321~333
Thomassen I / 2014 / Peritoneal carcinomatosis of gastric origin: a population-based study on incidence, survival and risk factors / Int J Cancer 134:622~628
Maeda H / 2015 / Evaluation and treatment of malignant ascites secondary to gastric cancer / World J Gastroenterol 21:10936~10947
Bartel DP / 2009 / MicroRNAs: target recognition and regulatory functions / Cell 136:215~233
Lin S / 2015 / MicroRNA biogenesis pathways in cancer / Nat Rev Cancer 15:321~333
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