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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제2호
- 발행연도
- 2019.1
- 수록면
- 200 - 208 (9page)
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Probiotics show low cell viability after oral administration because they have difficulty surviving in the stomach due to low pH and enzymes. For the oral delivery of probiotics, developing a formula that protects the probiotic bacteria from gastric acidity while providing living cells is mandatory. In this study, we developed tablets using a new pH-sensitive phthalyl inulin (PI) to protect probiotics from gastric conditions and investigated the effects of different compression forces on cell survival. We made three different tablets under different compression forces and measured survivability, disintegration time, and kinetics in simulated gastric-intestinal fluid. During tableting, there were no significant differences in probiotic viability among the different compression forces although disintegration time was affected by the compression force. A higher compression force resulted in higher viability in simulated gastric fluid. The swelling degree of the PI tablets in simulated intestinal fluid was higher than that of the tablets in simulated gastric fluid due to the pH sensitivity of the PI. The probiotic viability formulated in the tablets was also higher in acidic gastric conditions than that for probiotics in solution. Rapid release of the probiotics from the tablet occurred in the simulated intestinal fluid due to the pH sensitivity. After 6 months of refrigeration, the viability of the PI probiotics was kept. Overall, this is the first study to show the pH-sensitive properties of PI and one that may be useful for oral delivery of the probiotics.
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참고문헌 (41)
참고문헌 신청
Kechagia M / 2013 / Health benefits of probiotics : a review / ISRN Nutr 2013:481651
Forkus B / 2017 / Antimicrobial probiotics reduce salmonella enterica in turkey gastrointestinal tracts / Sci. Rep 7:40695
Doyle MP / 2006 / Reducing the carriage of foodborne pathogens in livestock and poultry / Poult. Sci 85:960~973
Dowarah R / 2017 / The use of Lactobacillus as an alternative of antibiotic growth promoters in pigs : a review / Anim. Nutr 3:1~6
Lee JY / 2017 / Pan-genomic approaches in lactobacillus reuteri as a porcine probiotic : investigation of host adaptation and antipathogenic activity / Microb. Ecol 74:709~721
Forkus B / 2017 / Antimicrobial probiotics reduce salmonella enterica in turkey gastrointestinal tracts / Sci. Rep 7:40695
Doyle MP / 2006 / Reducing the carriage of foodborne pathogens in livestock and poultry / Poult. Sci 85:960~973
Dowarah R / 2017 / The use of Lactobacillus as an alternative of antibiotic growth promoters in pigs : a review / Anim. Nutr 3:1~6
Lee JY / 2017 / Pan-genomic approaches in lactobacillus reuteri as a porcine probiotic : investigation of host adaptation and antipathogenic activity / Microb. Ecol 74:709~721
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