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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 264 - 270 (7page)
이용수
초록· 키워드
오류제보하기
Background: To develop a rabbit epidural steroid injection (ESI) model for analyzing steroid retention in the tissue, and to assess the difference in steroid retention in the model according to the location and time elapsed after ESI. Methods: Fluoroscopy-guided ESI was performed using the interlaminar approach between the lowest two lumbar segments in 13 female New Zealand white rabbits. Four rabbits were allocated to each of three different groups according to the time of sacrifice: 3, 7, and 15 days post-ESI; the remaining rabbit was sacrificed immediately post-ESI to obtain baseline data. After sacrifice, two segments were harvested: the lowest two lumbar vertebrae and another two lumbar vertebrae immediately above these. The residual steroid amount (RSA) and residual steroid concentration (RSC) in the collected spinal columns were analyzed. A linear mixed model was used to compare RSAs and RSCs between the injected and adjacent segments, and among the number of days until sacrifice; P < 0.05 was considered statistically significant. Results: Both RSA and RSC of the injected segment were significantly higher than those of the adjacent segment (P < 0.001, both). The RSA and RSC significantly decreased over time (P = 0.009 and P = 0.016, respectively). Conclusions: The developed rabbit ESI model verified that significantly more steroid was retained at the injected segment than at the adjacent segment and the residual steroid decreased over time. This model could be useful not only for comparing current steroid medications, but also for developing new, better steroid formulations.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Jacobs JM / 2006 / Chronic back pain among the elderly: prevalence, associations, and predictors / Spine (Phila Pa 1976) 31:E203~E207
Manchikanti L / 2015 / An updated assessment of utilization of interventional pain management techniques in the Medicare population : 2000-2013 / Pain Physician 18:E115~E127
Chou R / 2009 / Interventional therapies, surgery, and interdisciplinary rehabilitation for low back pain: an evidence-based clinical practice guideline from the American Pain Society / Spine (Phila Pa 1976) 34:1066~1077
Manchikanti L / 2015 / Do epidural injections provide short-and long-term relief for lumbar disc herniation? A systematic review / Clin Orthop Relat Res 473:1940~1956
Friedly JL / 2014 / A randomized trial of epidural glucocorticoid injections for spinal stenosis / N Engl J Med 371:11~21
Manchikanti L / 2015 / An updated assessment of utilization of interventional pain management techniques in the Medicare population : 2000-2013 / Pain Physician 18:E115~E127
Chou R / 2009 / Interventional therapies, surgery, and interdisciplinary rehabilitation for low back pain: an evidence-based clinical practice guideline from the American Pain Society / Spine (Phila Pa 1976) 34:1066~1077
Manchikanti L / 2015 / Do epidural injections provide short-and long-term relief for lumbar disc herniation? A systematic review / Clin Orthop Relat Res 473:1940~1956
Friedly JL / 2014 / A randomized trial of epidural glucocorticoid injections for spinal stenosis / N Engl J Med 371:11~21
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