Hepatocellular carcinoma in old age: are there any benefits of liver resection in old age?

In Sik Shin; Deok Gie Kim; Sung Whan Cha; Seong Hee Kang; Sung Hoon Kim; Moon Young Kim; Soon Koo Baik

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자료유형: 학술저널

저자정보: In Sik Shin (Yonsei University Wonju College of Medicine) Deok Gie Kim (Yonsei University Wonju College of Medicine) Sung Whan Cha (Yonsei University Wonju College of Medicine) Seong Hee Kang (Yonsei University Wonju College of Medicine) Sung Hoon Kim (Yonsei University Wonju College of Medicine) Moon Young Kim (Yonsei University Wonju College of Medicine) Soon Koo Baik (Yonsei University Wonju College of Medicine)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.99 No.2

발행연도: 2020.8

수록면: 65 - 71 (7page)

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Purpose: Elderly individuals have comorbidities that can adversely affect surgical outcomes. Some studies reported that elderly patients with hepatocellular carcinoma (HCC) have higher liver- and non-liver–related deaths. Therefore, palliative treatments are preferred in these patients. We compared surgical treatment outcomes between young and old age groups.
Methods: In total, 233 liver resections were performed in patients with HCC from March 2012 to December 2018. We retrospectively reviewed medical records. The old age group was defined as patients aged more than 70 years. We compared perioperative characteristics and surgical outcomes and analyzed the prognostic factors for disease-free survival (DFS) and overall survival (OS) rates.
Results: The young and old age group included 184 and 49 patients, respectively. Preoperative characteristics were similar. Major liver resection rate was similar (young age group, 26.1% vs. old age group, 20.4%), but the operation time was a little bit shorter in old age group. Major postoperative complications were 23 (12.5%) and 9 (18.4%) in the young and old age group (P = 0.351). Median non-liver–related overall survival were 80 and 76 months (P = 0.889) and liver-related OS were 76 and 76 months (P = 0.514) in the young and old age groups, respectively. Age was not an independent risk factor for DFS and OS.
Conclusion: Elderly patients showed similar non-liver- and liver-related OS rates as young patients after liver resection. Postoperative complications were also similar. If elderly patients are well selected, they can receive curative treatment and show good surgical outcomes.

#Hepatocellular carcinoma #Non-liver–related overall survival #Old age #Young age

참고문헌 (28)

참고문헌 신청

Kaibori M / 2019 / Impact of advanced age on survival in patients undergoing resection of hepatocellular carcinoma : report of a Japanese nationwide survey / Ann Surg 269:692~699

National Cancer Information Center / Major cancer mortality

Jung M / 2015 / National Cancer Screening Programs and evidence-based healthcare policy in South Korea / Health Policy 119:26~32

Kim SH / 2013 / Early predictor of mortality due to irreversible posthepatectomy liver failure in patients with hepatocellular carcinoma / World J Surg 37:1028~1033

Turrentine FE / 2006 / Surgical risk factors, morbidity, and mortality in elderly patients / J Am Coll Surg 203:865~877

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