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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 54 - 62 (9page)
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초록· 키워드
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Post-traumatic stress disorder (PTSD) is a stress-related psychiatric/mental condition. Tangeretin (TAN), a major polymethoxylated flavone of citrus plants, exhibits anti-inflammatory and neuroprotective activities. However, whether TAN leads to cognitive improvement in PTSD patients remains unclear. In the present study, we explored whether TAN improved cognitive impairment induced in rats by single prolonged stress (SPS episode mimicking PTSD induction) and determined whether TAN reversed reductions in dopamine (DA) and serotonin (5-HT) levels. Rats were intraperitoneally injected with TAN for 14 consecutive days after the SPS, which had induced cognitive deficits evident in the object recognition task and the Morris water maze test; the impairments were improved by TAN (100 mg/kg). TAN rescued the neurochemical abnormalities and the SPS-induced decreases in DA and 5-HT levels in the hippocampus and amygdala. These effects may be attributable in part to induction of hippocampal genes encoding tyrosine hydroxylase and tryptophan hydroxylase-1. Our results support the idea that rats with PTSD exhibit changes in DAergic and serotonergic transmission and in memory impairment. Thus, TAN mediated reversal of memory-related behavioral dysfunction associated with traumatic stress may be a useful therapeutic intervention in PTSD patients.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Aykac A / 2012 / The change in muscarinic receptor subtypes in different brain regions of rats treated with fluoxetine or propranolol in a model of post-traumatic stress disorder / Behav Brain Res 232:124~129
Bi J / 2016 / Nobiletin ameliorates isofluraneinduced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats / Mol Med Rep 14:5408~5414
Chen D / 2011 / Association between the TPH1 A218C polymorphism and risk of mood disorders and alcohol dependence: evidence from the current studies / J Affect Disord 138:27~33
Choi SY / 2007 / Correlation between flavonoid contentand the NO production inhibitory activity of peel extracts from various citrusfruits / Biol Pharm Bull 30:772~778
Datla KP / 2001 / Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease / Neuroreport 12:3871~3875
Bi J / 2016 / Nobiletin ameliorates isofluraneinduced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats / Mol Med Rep 14:5408~5414
Chen D / 2011 / Association between the TPH1 A218C polymorphism and risk of mood disorders and alcohol dependence: evidence from the current studies / J Affect Disord 138:27~33
Choi SY / 2007 / Correlation between flavonoid contentand the NO production inhibitory activity of peel extracts from various citrusfruits / Biol Pharm Bull 30:772~778
Datla KP / 2001 / Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease / Neuroreport 12:3871~3875
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