지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: The study is aimed at evaluating the possible toxicity in 90-day repeated oral administration of modified Samjung-hwan (mSJH) in Sprague-Dawley (SD) rats. This study was conducted to detect the no-observed adverse effect level (NOAEL). Methods: Modified SJH extract was administered orally in male and female SD rats at dose of 0, 1,000, 2,000, 4,000 mg/kg. Each group consisted of 10 rats of each gender. The modified SJH extract was given once a day for 90 days. We monitored the changes of mortalities, clinical signs, body weight changes, food consumption, ophthalmologic findings, urine analysis, hematology, serum biochemistry, necropsy findings, organ weights, histological markers of all animals treated with modified SJH extract during the study period. Results: There were no toxicologically significant changes in mortalities, clinical signs, body weight gains, food consumption, ophthalmologic findings, urine analysis, hematology, serum biochemistry, necropsy findings, organ weights, histological markers in any of rats tested. Conclusions: The NOAEL of the modified SJH extract in male rats and no observed effect level (NOEL) in female rats are considered 4,000 mg/kg.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Ballantyne CM / 2009 / Dyslipidemia & Atherosclerosis Essentials 2009 / Jones & Bartlett Publishers :5
Jee SH / 2014 / A coronary heart disease prediction model: the Korean Heart Study / BMJ Open 4(5):e005025
Committee for Guidelines for Management of Dyslipidemia / 2015 / 2015 Korean guidelines for management of dyslipidemia / J Lipid Atheroscler 4(1):61~92
Khader YS / 2010 / Prevalence of dyslipidemia and its associated factors among Jordanian adults / J Clin Lipidol 4(1):53~58
Wang S / 2011 / Prevalence and associated factors of dyslipidemia in the adult Chinese population / PLoS One 6(3):e17326
Jee SH / 2014 / A coronary heart disease prediction model: the Korean Heart Study / BMJ Open 4(5):e005025
Committee for Guidelines for Management of Dyslipidemia / 2015 / 2015 Korean guidelines for management of dyslipidemia / J Lipid Atheroscler 4(1):61~92
Khader YS / 2010 / Prevalence of dyslipidemia and its associated factors among Jordanian adults / J Clin Lipidol 4(1):53~58
Wang S / 2011 / Prevalence and associated factors of dyslipidemia in the adult Chinese population / PLoS One 6(3):e17326
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
삼정환의 랫드를 이용한 단회 경구투여 독성시험
한방비만학회지
2017 .01
-
Repeated dose 90-day oral toxicity of Kaolin in Spraque-Dawley (SD) rats
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Sprague-Dawley계 흰쥐를 이용한 HT042의 14일 반복 경구투여 독성연구
대한본초학회지(본초분과학회지)
2017 .01
-
Evaluation of 28-day repeated oral dose toxicity of aluminum chloride in rats
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Evaluation of 28-day repeated oral dose toxicity of aluminum chloride in rats
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Acute and Repeated 28-Day Oral Dose Toxicity Studies of Thymus vulgaris L. Essential Oil in Rats
Toxicological Research
2019 .07
-
A Study on the Single-dose Oral Toxicity of Super Key in Sprague-Dawley Rats
Journal of Pharmacopuncture
2015 .01
-
Repeated-dose 90-day oral toxicity study of GST in Sprague-Dawley rats
Environmental Analysis Health and Toxicology
2022 .06
-
Single dose oral toxicity study of a water extract of Gekko gecko in Sprague-Dawley rats
Journal of Biomedical and Translational Research
2024 .06
-
Toxicological assessment of Bromochlorophene: single and repeated-dose 28-day oral toxicity study in Sprague–Dawley rats
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Repeated-dose 28-day dermal toxicity study of TiO₂ catalyst (GST) in Sprague-Dawley rats
Environmental Analysis Health and Toxicology
2022 .06
-
Two-Week Repeated Dose Toxicity of Atractylodis Rhizoma Alba in F344 Rats
Natural Product Sciences
2016 .09
-
Acute and repeated dose 26-week oral toxicity study of 20(S)-ginsenoside Rg3 in Kunming mice and Sprague-Dawley rats
Journal of Ginseng Research
2020 .03
-
Effect of 28-day repeated oral dose toxicity of aluminum chloride(AlCl3) in rat
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Acute and 28-Day Subacute Toxicity Studies of Hexane Extracts of the Roots of Lithospermum erythrorhizon in Sprague-Dawley Rats
Toxicological Research
2015 .12
-
원지 추출물의 랫드에서 2주 반복 경구투여 독성평가
생약학회지(Korean Journal of Pharmacognosy)
2015 .03
-
산수유, 보골지 복합추출물의 Sprague-Dawley rat를 이용한 단회경구투여 독성시험
대한본초학회지(본초분과학회지)
2019 .01
-
HBX-6의 Sprague-Dawley rat를 이용한 단회경구투여 독성시험
대한본초학회지(본초분과학회지)
2018 .01
-
28-day repeated dose study of Chlorobutanol : Renal toxics
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Comparative analysis of historical background data of 13-week repeated toxicity study between Sprague-Dawley rat and Fischer 344 rat
한국실험동물학회 학술발표대회 논문집
2022 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0