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논문 기본 정보

자료유형
학술저널
저자정보
Baek, Jin-Hee (National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University) Kim, Jae-Ick (National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University) Kaang, Bong-Kiun (National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University)
저널정보
한국통합생물학회 Animal cells and systems Animal cells and systems 제13권 제4호
발행연도
2009.1
수록면
357 - 362 (6page)

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Hesperidin, the most abundant polyphenolic compound found in citrus fruits, has been known to possess neuroprotective, sedative, and anticonvulsive effects on the nervous system. In a recent electrophysiological study, it was reported that hesperidin induced biphasic change in population spike amplitude in hippocampal CA1 neurons in response to both single spike stimuli and theta-burst stimulation depending on its concentration. However, the precise mechanism by which hesperidin acts on neuronal functions has not been fully elucidated. Here, using whole-cell patch-clamp recording, we revealed that hesperidin did not affect excitatory synaptic activities such as basal synaptic transmission and theta-burst LTP. Moreover, in a current injection experiment, spike number, resting membrane potential and action potential threshold also remained unchanged. Taken together, these results indicate that the effects of hesperidin on the neuronal functions such as spiking activity might not be attributable to either modification of excitatory synaptic transmissions or changes in membrane excitability in hippocampal CA1 neuron.

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