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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 87 - 98 (12page)
- DOI
- 10.7841/ksbbj.2021.36.2.87
이용수
DBpia Top 5%동일한 주제분류 기준으로최근 2년간 이용수 순으로 정렬했을 때
해당 논문이 위치하는 상위 비율을 의미합니다.
초록· 키워드
오류제보하기
Biopharmaceutical drugs have strong therapeutic effect in various diseases such as autoimmune diseases, rheumatism and cancer due to their target specific recognition and low side effects. In particular, the most representative antibodies among biopharmaceuticals are widely used for targeted drug delivery, diagnosis and treatment. Moreover, antibody-drug conjugate (ADC) have been developed by many researchers and biopharmaceutical companies. An antibody-drug conjugate, one of the new bio anticancer drugs is composed of an antibody, cytotoxic drug and chemical linker. Antibodies accurately recognize the target cancer, and drugs induce apoptosis or death of the cancer cells. Linkers stably connects the antibody and drug until ADC go to the target cancer cells. In order to develop an ADC, it is important to correctly configure each component. Recently, the 9th ADC was approved by food and drug administration (FDA) and a lot of development of new ADC is underway. The development of ADC is expected through the introduction of new antibodies including bi-specific and drugs with new anticancer mechanisms.
목차
Abstract
1. INTRODUCTION
2. 바이오의약품 시장 동향과 ADC
3. ADC 구조
4. FDA approved ADC
5. 항체-약물 접합체 개발 동향
6. CONCLUSION
REFERENCES
참고문헌 (90)
참고문헌 신청
Elgundi, Z. / 2017 / The state-of-play and future of antibody therapeutics / Adv Drug Deliv Rev 122:2~19
Scott, A. M. / 2012 / Antibody therapy of cancer / Nat Rev Cancer 12:278~287
Lu, R. M. / 2020 / Development of therapeutic antibodies for the treatment of diseases / J Biomed Sci 27:1
Schirrmacher, V. / 2019 / From chemotherapy to biological therapy : A review of novel concepts to reduce the side effects of systemic cancer treatment(Review) / Int J Oncol 54:407~419
Korea, T. e.-i. b. o. / 2019 / Global biopharmaceutical industry trends and prospects
Scott, A. M. / 2012 / Antibody therapy of cancer / Nat Rev Cancer 12:278~287
Lu, R. M. / 2020 / Development of therapeutic antibodies for the treatment of diseases / J Biomed Sci 27:1
Schirrmacher, V. / 2019 / From chemotherapy to biological therapy : A review of novel concepts to reduce the side effects of systemic cancer treatment(Review) / Int J Oncol 54:407~419
Korea, T. e.-i. b. o. / 2019 / Global biopharmaceutical industry trends and prospects
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UCI(KEPA) : I410-ECN-0101-2021-470-001849481