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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 118 - 121 (4page)
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초록· 키워드
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In cancer patients, transfusion with blood components immediately before, during or after major surgery is common. The most common causes of red blood cell (RBC) administration blood loss and hemodilution and transfusion-related immune modulation is well-known adverse effect following transfusion of blood product. An impaired immune surveillance system as a consequence of the administration of substance in packed RBCs (residual viable leucocytes, various biological response modifiers present, and apoptotic cell) has been linked to cancer recurrence and progression. Of importance, the cancer cells can complete the metastatic cascade during the initial few days to weeks after surgery. Thus, the perioperative period is a critical time window for cancer recurrence, and it is of cardinal importance to reduce the exposure of allogeneic blood and to develop preemptive approaches to reduce the immunomodulatory effects of RBC transfusion for recipients who are already vulnerable to metastasis due to surgery-induced stress, inflammation, and immunosuppression. This lecture attempts to provide an overview of anesthetic strategies to reduce the negative impact of allogeneic RBC transfusion on postoperative cancer metastasis and recurrence based on research outcomes from our center.
목차
1. Blood conservation strategy: Intravenous iron injection
2. Blood conservation strategy: Intraoperative use of blood salvage and autotransfusion
3. RBC product modification and oncologic outcome
4. RBC storage duration and oncologic outcome
References
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UCI(KEPA) : I410-ECN-0101-2021-514-001919298