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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 44 - 58 (15page)
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초록· 키워드
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Natural killer (NK) cells, key antitumor effectors of the innateimmune system, are endowed with the unique ability to spontaneouslyeliminate cells undergoing a neoplastic transformation. Given their broad reactivity against diverse types ofcancer and close association with cancer prognosis, NK cellshave gained considerable attention as a promising therapeutictarget for cancer immunotherapy. NK cell-based therapies havedemonstrated favorable clinical efficacies in several hematologicalmalignancies but limited success in solid tumors, thushighlighting the need to develop new therapeutic strategies torestore and optimize anti-tumor activity while preventing tumorimmune escape. The current therapeutic modalities yieldingencouraging results in clinical trials include the blockade of immunecheckpoint receptors to overcome the immune-evasionmechanism used by tumors and the incorporation of tumor-directedchimeric antigen receptors to enhance NK cell anti-tumorspecificity and activity. These observations, together with recentadvances in the understanding of NK cell activation within thetumor microenvironment, will facilitate the optimal design ofNK cell-based therapy against a broad range of cancers and,more desirably, refractory cancers.
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참고문헌 (141)
참고문헌 신청
Larkin J / 2015 / Combined Nivolumab and Ipilimumab or monotherapy in untreated melanoma / N Engl J Med 373:23~34
Ishida Y / 1992 / Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death / EMBO J 11:3887~3895
Selvakumar A / 1992 / Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7 / Immunogenetics 36:175~181
Karre K / 1986 / Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy / Nature 319:675~678
Kim S / 2005 / Licensing of natural killer cells by host major histocompatibility complex class I molecules / Nature 436:709~713
Ishida Y / 1992 / Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death / EMBO J 11:3887~3895
Selvakumar A / 1992 / Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7 / Immunogenetics 36:175~181
Karre K / 1986 / Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy / Nature 319:675~678
Kim S / 2005 / Licensing of natural killer cells by host major histocompatibility complex class I molecules / Nature 436:709~713
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Effect of Diesels Exhaust Particle (DEP) on cytotoxicity of Natural killer cells
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