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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제55권 제2호
- 발행연도
- 2021.1
- 수록면
- 112 - 117 (6page)
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초록· 키워드
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Background: Langerhans cell histiocytosis (LCH) is more common in children than adults and involves many organs. In children, the BRAF V600E mutation is associated with recurrent and high-risk LCH. Methods: We collected paraffin blocks of 94 pediatric LCH patients to detect BRAF V600E mutation by sequencing. The relationship between BRAF V600E status and clinicopathological parameters were also critically analyzed. Results: BRAF V600E mutation exon 15 was detected in 45 cases (47.9%). Multiple systems LCH showed a significantly higher BRAF V600E mutation rate than a single system (p = .001). No statistical significance was evident for other clinical characteristics such as age, sex, location, risk organs involvement, and CD1a expression. Conclusions: In Vietnamese LCH children, the proportion of BRAF V600E mutational status was relatively high and related to multiple systems.
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참고문헌 (27)
참고문헌 신청
Guyot-Goubin A / 2008 / Descriptive epidemiology of childhood Langerhans cell histiocytosis in France, 2000-2004 / Pediatr Blood Cancer 51:71~75
Salotti JA / 2009 / Incidence and clinical features of Langerhans cell histiocytosis in the UK and Ireland / Arch Dis Child 94:376~380
Arceci RJ / 1999 / The histiocytoses : the fall of the Tower of Babel / Eur J Cancer 35:747~767
Gadner H / 2013 / Therapy prolongation improved outcome in multisystem Langerhans cell histiocytosis / Blood 121:5006~5014
Abla O / 2015 / Treatment of Langerhans cell histiocytosis : role of BRAF/MAPK inhibition / Hematology Am Soc Hematol Educ Program 2015:565~570
Salotti JA / 2009 / Incidence and clinical features of Langerhans cell histiocytosis in the UK and Ireland / Arch Dis Child 94:376~380
Arceci RJ / 1999 / The histiocytoses : the fall of the Tower of Babel / Eur J Cancer 35:747~767
Gadner H / 2013 / Therapy prolongation improved outcome in multisystem Langerhans cell histiocytosis / Blood 121:5006~5014
Abla O / 2015 / Treatment of Langerhans cell histiocytosis : role of BRAF/MAPK inhibition / Hematology Am Soc Hematol Educ Program 2015:565~570
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