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학술저널
저자정보
피규영 (서울아산병원) 공은정 (울산대학교) 최지영 (서울아산병원) 김민주 (서울아산병원) 안지용 (서울아산병원) 최재원 (울산대학교) 배서은 (서울아산병원) 장혜숙 (울산대학교) 나희경 (서울아산병원) 이정훈 (울산대학교) 정기욱 (서울아산병원) 김도훈 (서울아산병원) 최기돈 (울산대학교) 송호준 (울산대학교) 이진혁 (서울아산병원) 정훈용 (울산대학교)
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제53권 제2호
발행연도
2021.1
수록면
445 - 456 (12page)

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Purpose The association of serum lipids with gastric cancer is controversial. We clarified the role of serum lipids in the development, progression, and prognosis of gastric cancer.Materials and Methods In total, 412 patients diagnosed with gastric cancer were prospectively recruited, and 2,934 control subjects who underwent screening endoscopy were enrolled from December 2013 to March 2017 to conduct a case-control study in a tertiary center. Serum lipid profiles, including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), apolipoprotein A-I (apoA-I), and apolipoprotein B, and clinicopathologic characteristics were analyzed.Results The gastric cancer group showed significantly lower HDL-C, higher LDL-C, and lower apoA-I level than the control group. In multivariate analysis, old age (odds ratio [OR], 1.051; p < 0.001), smoking (OR, 1.337; p < 0.001), a family history of gastric cancer (OR, 2.038; p < 0.001), Helicobacter pylori seropositivity (OR, 4.240; p < 0.001), lower HDL-C (OR, 0.712; p=0.020), and higher LDL-C (p=0.002) were significant risk factors for gastric cancer. Lower HDL-C and higher LDL-C remained significant after adjustments for covariates, including age and sex. In a subgroup analysis of the gastric cancer group, lower TG levels were associated with undifferentiated histology. No serum lipids were associated with overall survival.Conclusion Lower HDL-C and higher LDL-C were associated with the risk of gastric cancer, even after adjusting for age, sex, and other factors. In the gastric cancer group, undifferentiated histology was associated with lower TG levels.

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