Immunologic Aspects of Dyslipidemia: a Critical Regulator of Adaptive Immunity and Immune Disorders

김대홍; 정하연; 이정은; 김지연; 황준석; 정연석

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자료유형: 학술저널

저자정보: 김대홍 (Laboratory of Immune Regulation Institute of Pharmaceutical Sciences College of Pharmacy Seoul Nati) 정하연 (Laboratory of Immune Regulation Institute of Pharmaceutical Sciences College of Pharmacy Seoul Nati) 이정은 (Laboratory of Immune Regulation Institute of Pharmaceutical Sciences College of Pharmacy Seoul Nati) 김지연 (Laboratory of Immune Regulation Institute of Pharmaceutical Sciences College of Pharmacy Seoul Nati) 황준석 (Laboratory of Immune Regulation Institute of Pharmaceutical Sciences College of Pharmacy Seoul Nati) 정연석 (서울대학교)

저널정보: 한국지질동맥경화학회(구 한국지질학회) 지질·동맥경화학회지 지질·동맥경화학회지 제10권 제2호

발행연도: 2021.1

수록면: 184 - 201 (18page)

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Dyslipidemia is a major cause of cardiovascular diseases which represent a leading cause of death in humans. Diverse immune cells are known to be involved in the pathogenesis of cardiovascular diseases such as atherosclerosis. Conversely, dyslipidemia is known to be tightly associated with immune disorders in humans, as evidenced by a higher incidence of atherosclerosis in patients with autoimmune diseases including psoriasis, rheumatoid arthritis, and systemic lupus erythematosus. Given that the dyslipidemia-related autoimmune diseases are caused by autoreactive T cells and B cells, dyslipidemia seems to directly or indirectly regulate the adaptive immunity. Indeed, accumulating evidence has unveiled that proatherogenic factors can impact the differentiation and function of CD4+ T cells, CD8+ T cells, and B cells. This review discusses an updated overview on the regulation of adaptive immunity by dyslipidemia and proposes a potential therapeutic strategy for immune disorders by targeting lipid metabolism.

#Dyslipidemia #T cell #B cell Dendritic cell #Immune disorder

참고문헌 (108)

참고문헌 신청

Hansson GK / 2005 / Inflammation, atherosclerosis, and coronary artery disease / N Engl J Med 352:1685~1695

Weber C / 2011 / Atherosclerosis : current pathogenesis and therapeutic options / Nat Med 17:1410~1422

Hansson GK / 2006 / The immune response in atherosclerosis : a double-edged sword / Nat Rev Immunol 6:508~519

Weber C / 2008 / The multifaceted contributions of leukocyte subsets to atherosclerosis : lessons from mouse models / Nat Rev Immunol 8:802~815

Grundtman C / 2011 / The autoimmune concept of atherosclerosis / Curr Opin Lipidol 22:327~334

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