지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 282 - 289 (8page)
- DOI
- 10.14348/molcells.2018.2123
이용수
초록· 키워드
오류제보하기
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine mainly derived from T helper 17 cells and is known to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS) has been considered as a primary risk factor of COPD. However, the interaction between CS and IL-17A and the underlying molecular mechanisms have not been clarified. In the current study, we investigated the effects of cigarette smoke extract (CSE) on IL-17A-induced IL-8 production in human bronchial epithelial cells, and sought to identify the underlying molecular mechanisms. IL-8 production was significantly enhanced following treatment with both IL-17A and CSE, while treatment with either IL-17A or CSE alone caused only a slight increase in IL-8 production. CSE increased the transcription of IL-17RA/RC and surface membrane expression of IL-17R, which was suppressed by an inhibitor of the phosphoinositide 3-kinase (PI3K)/Akt pathway (LY294002). CSE caused inactivation of glycogen synthase kinase-3β (GSK-3β) via the PI3K/Akt pathway. Blockade of GSK-3β inactivation by overexpression of constitutively active GSK-3β (S9A) completely suppressed the CSE-induced up-regulation of IL-17R expression and the CSE-induced enhancement of IL-8 secretion. In conclusion, inactivation of GSK-3β via the PI3K/Akt pathway mediates CSE-induced up-regulation of IL-17R, which contributes to the enhancement of IL-17A-induced IL-8 production.
목차
등록된 정보가 없습니다.
참고문헌 (47)
참고문헌 신청
Aggarwal, S. / 2002 / IL-17: prototype member of an emerging cytokine family / J. Leukoc. Biol. 71:1~8
Bettelli, E. / 2007 / Th17: the third member of the effector T cell trilogy / Curr. Opin. Immunol. 19:652~657
Boyle, W.J. / 1991 / Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNAbinding activity / Cell 64:573~584
Burgler, S. / 2009 / Differentiation and functional analysis of human T(H)17 cells / J. Allergy Clin. Immunol. 123:588~595
Cazzola, M. / 2012 / IL-17 in chronic obstructive pulmonary disease / Expert. Rev. Respir. Med. 6:135~138
Bettelli, E. / 2007 / Th17: the third member of the effector T cell trilogy / Curr. Opin. Immunol. 19:652~657
Boyle, W.J. / 1991 / Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNAbinding activity / Cell 64:573~584
Burgler, S. / 2009 / Differentiation and functional analysis of human T(H)17 cells / J. Allergy Clin. Immunol. 123:588~595
Cazzola, M. / 2012 / IL-17 in chronic obstructive pulmonary disease / Expert. Rev. Respir. Med. 6:135~138
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Cell-Based IL-15:IL-15Rα Secreting Vaccine as an Effective Therapy for CT26 Colon Cancer in Mice
Molecules and Cells
2019 .01
-
In Vitro GATA-3-Mediated Inhibition of IL-1ß, IL-6 and IL-10 Expression in Allergy Caused by Bisphenol A by Lactobacillus plantarum L67 Extract
한국미생물학회 학술대회논문집
2015 .04
-
Characterization of the N-glycosylation of Recombinant IL-4 and IL-13 Proteins Using LC-MS/MS Analysis and the I-GPA Platform
Mass Spectrometry Letters
2021 .09
-
Efficient Interleukin-21 Production by Optimization of Codon and Signal Peptide in Chinese Hamster Ovarian Cells
Journal of Microbiology and Biotechnology
2019 .01
-
Bulb of Lilium longiflorum Thunb Extract Fermented with Lactobacillus acidophilus Reduces Inflammation in a Chronic Obstructive Pulmonary Disease Model
Journal of Microbiology and Biotechnology
2023 .05
-
Prolonged Exposure to Lipopolysaccharide Induces NLRP3-Independent Maturation and Secretion of Interleukin (IL)-1β in Macrophages
Journal of Microbiology and Biotechnology
2018 .01
-
Analysis and comparison of the volatile organic compounds between the cigarette smoke condensate (CSC) and extract (CSE) samples
한국분석과학회 학술대회
2017 .11
-
Interleukin-1β Participates in the Development of Pneumococcal Acute Lung Injury and Death by Promoting Alveolar Microvascular Leakage
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .06
-
Roles of Interleukin-17 and Th17 Responses in COVID-19
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2021 .09
-
IL-6-miR-210 Suppresses Regulatory T Cell Function and Promotes Atrial Fibrosis by Targeting Foxp3
Molecules and Cells
2020 .01
-
A Case of Widespread Dermatophytosis during Interleukin-17A Inhibitor Treatment in Psoriasis Patient with Tinea Unguium
대한의진균학회지
2019 .01
-
유근피 추출물이 대식세포 면역조절에 미치는 영향
생명과학회지
2016 .01
-
Agrobacterium sp.-derived β-1,3-glucan enhances natural killer cell activity in healthy adults : a randomized, double-blind, placebo-controlled, parallel-group study
Nutrition Research and Practice
2017 .02
-
Agrobacterium sp.-derived β-1,3-glucan enhances natural killer cell activity in healthy adults : a randomized, double-blind, placebo-controlled, parallel-group study
Nutrition Research and Practice
2017 .02
-
Inhibition of TNFα-induced interleukin-6 gene expression by barley (Hordeum vulgare) ethanol extract in BV-2 microglia
Genes & Genomics
2019 .01
-
마이봄샘기능저하증을 수반하는 염증성 건성안 감별을 위한 ‘TNF-α, IL-6, MMP-9’ 검사키트의 유용성 평가
대한시과학회지
2020 .01
-
Chungkookjang Ethanol Extracts reduces IL6 Expression
한국미생물학회 학술대회논문집
2015 .04
-
Cardamonin Inhibited IL-1β Induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO-1 Signaling Pathway in Chondrocyte
Journal of Microbiology and Biotechnology
2021 .01
-
Interleukin-9 Inhibits Lung Metastasis of Melanoma through Stimulating Anti-Tumor M1 Macrophages
Molecules and Cells
2020 .01
-
Modulation of IL-27p28 Production in Adaptive Immunity during Toxoplasma Infection
한국미생물학회 학술대회논문집
2020 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0