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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제2호
- 발행연도
- 2017.3
- 수록면
- 161 - 168 (8page)
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Understanding the crosstalk mechanisms between perivascular cells (PVCs) and cancer cells might be beneficial in preventing cancer development and metastasis. In this study, we investigated the paracrine influence of PVCs derived from human umbilical cords on the proliferation of lung adenocarcinoma epithelial cells (A549) and erythroleukemia cells (TF-1α and K562) in vitro using Transwellⓡ co-culture systems. PVCs promoted the proliferation of A549 cells without inducing morphological changes, but had no effect on the proliferation of TF-1α and K562 cells. To identify the factors secreted from PVCs, conditioned media harvested from PVC cultures were analyzed by antibody arrays. We identified a set of cytokines, including persephin (PSPN), a neurotrophic factor, and a key regulator of oral squamous cell carcinoma progression. Supplementation with PSPN significantly increased the proliferation of A549 cells. These results suggested that PVCs produced a differential effect on the proliferation of cancer cells in a cell-type dependent manner. Further, secretome analyses of PVCs and the elucidation of the molecular mechanisms could facilitate the discovery of therapeutic target(s) for lung cancer.
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참고문헌 (37)
참고문헌 신청
Ribeiro AL / 2015 / Combined effects of pericytes in the tumor microenvironment / Stem Cells Int
Hall AP / 2006 / Review of the pericyte during angiogenesis and its role in cancer and diabetic retinopathy / Toxicol Pathol 34:763~775
Hay E / 1991 / Unusual presentation of pheochromocytoma / Am J Emerg Med 9:399~402
Crisan M / 2008 / A perivascular origin for mesenchymal stem cells in multiple human organs / Cell Stem Cell 3:301~313
Baksh D / 2007 / Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow / Stem Cells 25:1384~1392
Hall AP / 2006 / Review of the pericyte during angiogenesis and its role in cancer and diabetic retinopathy / Toxicol Pathol 34:763~775
Hay E / 1991 / Unusual presentation of pheochromocytoma / Am J Emerg Med 9:399~402
Crisan M / 2008 / A perivascular origin for mesenchymal stem cells in multiple human organs / Cell Stem Cell 3:301~313
Baksh D / 2007 / Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow / Stem Cells 25:1384~1392
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