지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 641 - 654 (14page)
- DOI
- 10.4093/dmj.2021.0220
이용수
초록· 키워드
오류제보하기
The impaired insulin secretion and increased insulin resistance (or decreased insulin sensitivity) play a major role in the pathogenesis of all types of diabetes mellitus (DM). It is very important to assess the pancreatic β-cell function and insulin resistance/ sensitivity to determine the type of DM and to plan an optimal management and prevention strategy for DM. So far, various methods and indices have been developed to assess the β-cell function and insulin resistance/sensitivity based on static, dynamic test and calculation of their results. In fact, since the metabolism of glucose and insulin is made through a complex process related with various stimuli in several tissues, it is difficult to fully reflect the real physiology. In order to solve the theoretical and practical difficulties, research on new index is still in progress. Also, it is important to select the appropriate method and index for the purpose of use and clinical situation. This review summarized a variety of traditional methods and indices to evaluate pancreatic β-cell function and insulin resistance/sensitivity and introduced novel indices.
목차
등록된 정보가 없습니다.
참고문헌 (87)
참고문헌 신청
Chen L / 2011 / The worldwide epidemiology of type 2 diabetes mellitus : present and future perspectives / Nat Rev Endocrinol 8:228~236
DeFronzo RA / 2004 / Pathogenesis of type 2 diabetes mellitus / Med Clin North Am 88:787~835
UK Prospective Diabetes Study (UKPDS) Group / 1998 / Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) / Lancet 352:837~853
Viberti G / 2002 / A diabetes outcome progression trial(ADOPT) : an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes / Diabetes Care 25:1737~1743
Moller DE / 1991 / Insulin resistance : mechanisms, syndromes, and implications / N Engl J Med 325:938~948
DeFronzo RA / 2004 / Pathogenesis of type 2 diabetes mellitus / Med Clin North Am 88:787~835
UK Prospective Diabetes Study (UKPDS) Group / 1998 / Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) / Lancet 352:837~853
Viberti G / 2002 / A diabetes outcome progression trial(ADOPT) : an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes / Diabetes Care 25:1737~1743
Moller DE / 1991 / Insulin resistance : mechanisms, syndromes, and implications / N Engl J Med 325:938~948
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