지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.2
- 수록면
- 364 - 376 (13page)
- DOI
- 10.1038/s12276-023-00936-y
이용수
초록· 키워드
오류제보하기
Targeting bromodomain and extra-terminal domain (BET) proteins has shown a promising therapeutic effect on melanoma. The development of strategies to better kill melanoma cells with BET inhibitor treatment may provide new clinical applications. Here, we used a drug synergy screening approach to combine JQ1 with 240 antitumor drugs from the Food and Drug Administration (FDA)-approved drug library and found that sunitinib synergizes with BET inhibitors in melanoma cells. We further demonstrated that BET inhibitors synergize with sunitinib in melanoma by inducing apoptosis and cell cycle arrest. Mechanistically, BET inhibitors sensitize melanoma cells to sunitinib by inhibiting GDF15 expression. Strikingly, GDF15 is transcriptionally regulated directly by BRD4 or indirectly by the BRD4/IL6/STAT3 axis. Xenograft assays revealed that the combination of BET inhibitors with sunitinib causes melanoma suppression in vivo. Altogether, these findings suggest that BET inhibitor-mediated GDF15 inhibition plays a critical role in enhancing sunitinib sensitivity in melanoma, indicating that BET inhibitors synergize with sunitinib in melanoma.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Research progress on hydrogel-based drug therapy in melanoma immunotherapy
BMB Reports
2024 .02
-
Current Immunotherapy Approaches for Malignant Melanoma
BioChip Journal
2019 .01
-
Skin Lesion Classification towards Melanoma Diagnosis using Convolutional Neural Network and Image Enhancement Methods
한국지능시스템학회 논문지
2019 .06
-
JQ1, a BET inhibitor, controls TLR4-induced IL-10 production in regulatory B cells by BRD4-NF-κB axis
BMB Reports
2017 .01
-
컨볼루션 신경망을 활용한 말단 악성 흑색종의 깊이 분류 모델
대한전자공학회 학술대회
2021 .11
-
Melanoma Classification Using Log-Gabor Filter and Ensemble of Deep Convolution Neural Networks
멀티미디어학회논문지
2022 .08
-
나노다공체 물성 측정을 위한 극저온(20K) 수소 BET 개발 및 응용
한국재료학회지
2017 .01
-
항암제 개발: 토포아이소머라제, HSP90, mTOR 및 티로신키나제 억제제
KSBB Journal
2021 .06
-
Inhibition of Metastatic Melanoma through Nano-micelle Generating Microneedles Including Doxorubicin
한국생물공학회 학술대회
2020 .06
-
(주)케이베츠
대한토목학회지
2020 .08
-
딥 러닝 기반의 악성흑색종 분류를 위한 컴퓨터 보조진단 알고리즘
디지털산업정보학회논문지
2018 .01
-
Upconversion-based Photodynamic Therapy Synergized with an Immune Checkpoint Inhibitor for Enhanced Cancer Treatment
한국고분자학회 학술대회 연구논문 초록집
2023 .10
-
Efficient Melanoma Treatment Using B16F10-sensitive Toxicity of Gold Nanorods
한국생물공학회 학술대회
2023 .04
-
Enhancing Melanoma Therapeutic Efficiency with Multi-Gene Editing Using CRISPR-Cas9 System
한국생물공학회 학술대회
2024 .09
-
회색도 변환 행렬 특징과 SVM을 이용한 흑색종 분류 알고리즘
멀티미디어학회논문지
2018 .02
-
Inhibitory Effects on Melanin Production in B16 Melanoma Cells of fractions from Schisandra chinensis
한국고분자학회 학술대회 연구논문 초록집
2019 .10
-
Tumor antigen PRAME is a potential therapeutic target of p53 activation in melanoma cells
BMB Reports
2024 .06
-
Multi-drug Targeted Delivery System Using Recombinant Fusion Protein with Drug Specific Binding Domain
한국생물공학회 학술대회
2023 .04
-
An engineered PD-1-based and MMP-2/9-oriented fusion protein exerts potent antitumor effects against melanoma
BMB Reports
2018 .01
-
Inhibition of Metastatic Melanoma through Nano-micelle Generating Degradable Microneedles Including Chemotherapy Drug
한국생물공학회 학술대회
2021 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0