지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.3
- 수록면
- 153 - 159 (7page)
이용수
초록· 키워드
오류제보하기
Neuronal differentiation is highly coordinated through a cascadeof gene expression, mediated via interactions between transactingtranscription factors and cis-regulatory elements of theirtarget genes. However, the mechanisms of transcriptional regulationthat determine neuronal cell-fate are not fully understood. Here, we show that the nuclear transcription factor Y(NF-Y) subunit, NFYA-1, is necessary and sufficient to expressthe flp-3 neuropeptide gene in the IL1 neurons of C. elegans. flp-3 expression is decreased in dorsal and lateral, but notventral IL1s of nfya-1 mutants. The expression of another terminallydifferentiated gene, eat-4 vesicular glutamate transporter,is abolished, whereas the unc-8 DEG/ENaC gene and pan-neuronalgenes are expressed normally in IL1s of nfya-1 mutants. nfya-1 is expressed in and acts in IL1s to regulate flp-3 andeat-4 expression. Ectopic expression of NFYA-1 drives the expressionof flp-3 gene in other cell-types. Promoter analysis ofIL1-expressed genes results in the identification of several cisregulatorymotifs which are necessary for IL1 expression, includinga putative CCAAT-box located in the flp-3 promoterthat NFYA-1 directly interacts with. NFYA-1 and NFYA-2, togetherwith NFYB-1 and NFYC-1, exhibit partly or fully redundantroles in the regulation of flp-3 or unc-8 expression, respectively. Taken together, our data indicate that the NF-Ycomplex regulates neuronal subtype-specification via regulatinga set of terminal-differentiation genes.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A Genetic Switch for Chemical High-Producing Escherichia coli using Flp-recombinase
한국생물공학회 학술대회
2015 .10
-
IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation
Experimental and Molecular Medicine
2017 .01
-
IL-30† (IL-27A): a familiar stranger in immunity, inflammation, and cancer
Experimental and Molecular Medicine
2021 .05
-
Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease
Experimental and Molecular Medicine
2024 .06
-
Regulation of cellular gene expression by nanomaterials
Nano Convergence
2018 .11
-
재구성제조시스템에서 설비배치와 Job Shop 스케줄링의 통합 최적화에 관한 연구
대한산업공학회지
2022 .02
-
Predicting Gene Expressions from Gene Expressions : Comparison between Lasso and Random Forest
한국정보과학회 학술발표논문집
2018 .06
-
A neutrophil elastase-generated mature form of IL-33 is a potent regulator of endothelial cell activation and proliferative retinopathy
Experimental and Molecular Medicine
2024 .08
-
JQ1, a BET inhibitor, controls TLR4-induced IL-10 production in regulatory B cells by BRD4-NF-κB axis
BMB Reports
2017 .01
-
Design of Polymeric Gene Carriers for Highly Efficient Gene Expression through Regulation of Cellular Uptake
한국고분자학회 학술대회 연구논문 초록집
2016 .10
-
IL-17A exacerbates diabetic retinopathy by impairing Müller cell function via Act1 signaling
Experimental and Molecular Medicine
2016 .01
-
Combined Method of Neuronal Cell-Inducible Vector and Valproic Acid for Enhanced Gene Expression under Hypoxic Conditions
조직공학과 재생의학
2020 .01
-
Enhancing Gene Expression Classification of Support Vector Machines with Generative Adversarial Networks
Journal of information and communication convergence engineering
2019 .03
-
Tunable Gene Expression System for the Development of a Genetically Engineered E. coli Strain
한국생물공학회 학술대회
2020 .10
-
Interleukin-32: Frenemy in cancer?
BMB Reports
2019 .01
-
Fine-tuning System for the Bacteria Gene Expression
한국생물공학회 학술대회
2021 .04
-
Development of a Deep Learning Model for Predicting the Effects of Cultivation Condition on Gene Expression Levels in Escherichia coli
한국생물공학회 학술대회
2021 .10
-
Coding sequence-independent, tunable gene expression toolbox for bacteria engineering
한국생물공학회 학술대회
2019 .10
-
Harnessing IL-2 for immunotherapy against cancer and chronic infection: A historical perspective and emerging trends
Experimental and Molecular Medicine
2024 .09
-
Entinostat, a histone deacetylase inhibitor, increases the population of IL-10+ regulatory B cells to suppress contact hypersensitivity
BMB Reports
2021 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0