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논문 기본 정보

자료유형
학술저널
저자정보
Lee Moeun (Fermentation Regulation Research Group, World Institute of Kimchi, Gwangju 61755, Republic of KoreaBiomodulation Major, Department of Agricultural Biotechnology, Seoul National University, S) Kim Daun (Fermentation Regulation Research Group, World Institute of Kimchi, Gwangju 61755, Republic of KoreaDepartment of Food and Nutrition, Chosun University, Gwangju 61452, Republic of Korea) Chang Ji Yoon (Fermentation Regulation Research Group, World Institute of Kimchi, Gwangju 61755, Republic of KoreaDivision of Food Science and Technology, Gyeongsang National University, Jinju 52828, Repub)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.2
발행연도
2024.2
수록면
306 - 313 (8page)
DOI
10.4014/jmb.2308.08015

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초록· 키워드

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Given the diversity of vegetables utilized in food fermentation and various lactic acid bacteria (LAB) populations in these materials, comprehensive studies on LAB from vegetable foods, including kimchi, are imperative. Therefore, this study aimed to investigate the obesity-related inflammation response of three metabolites—phenyllactic acid (PLA), indole-3-lactic acid (ILA), and leucic acid (LA)—produced by LAB (Companilactobacillus allii WiKim39 and Lactococcus lactis WiKim0124) isolated from kimchi. Their effects on tumor necrosis factor-α-induced changes in adipokines and inflammatory response in adipose-derived human mesenchymal stem cells were examined. The study results showed that PLA, ILA, and LA, particularly PLA, effectively reduced lipid accumulation and triglyceride, glycerol, free fatty acid, and adiponectin levels. Furthermore, the identified metabolites were found to modulate the expression of signaling proteins involved in adipogenesis and inflammation. Specifically, these metabolites were associated with enriched expression in the chemokine signaling pathway and cytokine-cytokine receptor interaction, which are critical pathways involved in regulating immune responses and inflammation. PLA, ILA, and LA also suppressed the secretion of pro-inflammatory cytokines and several inflammatory markers, with the PLA-treated group exhibiting the lowest levels. These results suggest that PLA, ILA, and LA are potential therapeutic agents for treating obesity and inflammation by regulating adipokine secretion and suppressing pro-inflammatory cytokine production.

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