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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 41 - 46 (6page)
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초록· 키워드
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The apoptosis of macrophages occurs throughout all stages of atherosclerosis. It is known to constitute atheromatous plaque, increase plaque instability, and thus contribute to the development of atherosclerosis. However, there still remains much to be elucidated on how the apoptotic macrophages affect the endothelial cells and also how they contribute to the development of atherosclerosis. Here we present a microfluidic system, which enables co-culture of apoptotic macrophages and endothelial cells in fibrin gel that mimics in vivo extracellular matrix. With the system, we can investigate the effect of macrophage apoptosis on vascular endothelial cells by quantitatively analyzing the level of reactive oxygen species of HUVECs, integrity of VE-cadherin and cell proliferation. We expect that this system could be utilized further for understanding different mechanisms of apoptotic macrophage on the development of atherosclerosis.
목차
Abstract
1. 서론
2. 실험방법
3. 결과
4. 결론
REFERENCE
참고문헌 (13)
참고문헌 신청
Kim, M. H., Y. H. Jung, and D. H. Lee., 2015, Cardiovascular diseases prevention and control campaign, 2015. Public Health Wkly Rep, Vol. 8(39), pp. 925∼928.
Sander, Dirk, et al., 2000, Relationship between circadian blood pressure patterns and progression of early carotid atherosclerosis. Circulation, Vol. 102(13), pp. 1536∼1541.
Hansson GK, Hamsten A., 2016, Atherosclerosis, thrombosis, and vascular biology. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders: chap 70.
Tabas, Ira., 2005, Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology, Vol. 25(11), pp. 2255∼2264.
Silvestre-Roig, Carlos, et al., 2014, Atherosclerotic Plaque Destabilization. Circulation research, Vol. 114(1), pp. 214∼226.
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UCI(KEPA) : I410-ECN-0101-2018-505-001717627