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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 43 - 43 (1page)
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Topic 1 for Stent coating: Cardiovascular disease is the number one cause of death worldwide. Stents are the most commonly implanted devices to effectively treat cardiovascular disease. However, bare metal stent (BMS) remains limited by relatively high rates of in-stent restenosis and the accompanying extracellular matrix deposition. Thus, drug-eluting stents (DES) have been developed to reduce restenosis. Although these efforts were successful, DES has its own set of shortcomings: late stent thrombosis, inflammation and delayed re-endothelialization. To address these issues, we developed a novel prohealing multifunctional stent coating: a nitric oxide (NO)-releasing endothelium-mimicking nanomatrix composed of the biomaterial- Peptide Amphiphile (PA). We evaluated the safety and efficacy of the novel coated stent in the rabbit iliac artery balloon injury model and compared with commercially available BMS and DES. The goal is to demonstrate the advantages of the nanomatrix coating which could enhance re-endothelialization, while reduce restenosis, inflammation, and thrombosis. We hypothesize that the prohealing multifunctional nanomatrix coated stent has several strengths compared with BMS and DES: 1) promoted re-endothelialization; 2) less restenosis than BMS; and 3) less inflammation and thrombosis tha^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10550502');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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UCI(KEPA) : I410-ECN-0101-2021-578-001628761