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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 406 - 411 (6page)
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초록· 키워드
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Exosomes are small membranous vesicles which contain abundant RNA molecules, and are transferred from releasing cells to uptaking cells. MicroRNA (miRNA) is one of the transferred molecules affecting the adopted cells, including glioma cells. We hypothesized that mesenchymal stem cells (MSCs) can secrete exosomes loading miRNA and have important effects on the progress of gliomas. To determine these effects by treating exosomal miRNA in culture media of miRNA mimic transfected MSCs, we assessed the in vitro cell proliferation and invasion capabilities, and the expression level of relative proteins associated with cell apoptosis, growth and migration. For animal studies, the mice injected with U87 cells were exposed to exosomes derived from miRNA-584-5p transfected MSCs, to confirm the influence of exosomal miRNA on the progress of glioma. Based on our results, we propose a new targeted cancer therapy wherein exosomes derived from miRNA transfected MSCs could be used to modulate tumor progress as the anticancer vehicles.
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참고문헌 (31)
참고문헌 신청
Xu F / 2010 / Chemokines mediate mesenchymal stem cells migration toward gliomas in vitro / Oncol Rep 23:1561~1567
Yang C / 2014 / Conditioned media from human adipose tissue-derived mesenchymal stem cells and umbilical cord-derived mesenchymal stem cells efficiently induced the apoptosis and differentiation in human glioma cell lines in vitro / Biomed Res Int 2014:109389
Brandes AA / 2008 / Glioblastoma in adults / Crit Rev Oncol Hematol 67:139~152
He Y / 2016 / miR-124 functions as a tumor suppressor via targeting hCLOCK1 in glioblastoma / Mol Neurobiol
Liao A / 2016 / SDF-1/CXCR4 axis regulates cell cycle progression and epithelialmesenchymal transition via up-regulation of surviving in glioblastoma / Mol Neurobiol 53:210~215
Yang C / 2014 / Conditioned media from human adipose tissue-derived mesenchymal stem cells and umbilical cord-derived mesenchymal stem cells efficiently induced the apoptosis and differentiation in human glioma cell lines in vitro / Biomed Res Int 2014:109389
Brandes AA / 2008 / Glioblastoma in adults / Crit Rev Oncol Hematol 67:139~152
He Y / 2016 / miR-124 functions as a tumor suppressor via targeting hCLOCK1 in glioblastoma / Mol Neurobiol
Liao A / 2016 / SDF-1/CXCR4 axis regulates cell cycle progression and epithelialmesenchymal transition via up-regulation of surviving in glioblastoma / Mol Neurobiol 53:210~215
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