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- 학술저널
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- 2017.1
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The administration of mesenchymal stem cells (MSCs) as a therapy for liver disease holds great promise. MSCs can differentiate into hepatocytes, reduce liver inflammation, promote hepatic regeneration and secrete protective cytokines. However, the risks of iatrogenic tumor formation, cellular rejection and infusional toxicity in MSC transplantation remain unresolved. Accumulating evidence now suggests that a novel cell-free therapy, MSC-secreted exosomes, might constitute a compelling alternative because of their advantages over the corresponding MSCs. They are smaller and less complex than their parent cells and, thus, easier to produce and store, they are devoid of viable cells, and they present no risk of tumor formation. Moreover, they are less immunogenic than their parent cells because of their lower content in membrane-bound proteins. This paper reviews the biogenesis of MSC exosomes and their physiological functions, and highlights the specific biochemical potential of MSC-derived exosomes in restoring tissue homeostasis. In addition, we summarize the recent advances in the role of exosomes in MSC therapy for various liver diseases, including liver fibrosis, acute liver injury and hepatocellular carcinoma. This paper also discusses the potential challenges and strategies in the use of exosome-based therapies for liver disease in the future.
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참고문헌 (23)
참고문헌 신청
Arslan F / 2013 / Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prev
Braicu C / 2015 / Exosomes as divine messengers: are they the Hermes of modern molecular oncology? / Cell Death Differ 22 : 34 ~ 45
Christ B / 2015 / The therapeutic promise of mesenchymal stem cells for liver restoration / Trends Mol Med 21 : 673 ~ 686
Escola JM / 1998 / Selective enrichment of tetraspan proteins on the internal vesicles of mul-tivesicular endosomes and on exosomes secreted by human B-lymphocytes / J Biol
Gnecchi M / 2005 / Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells / Nat Med 11 : 367 ~ 368
Braicu C / 2015 / Exosomes as divine messengers: are they the Hermes of modern molecular oncology? / Cell Death Differ 22 : 34 ~ 45
Christ B / 2015 / The therapeutic promise of mesenchymal stem cells for liver restoration / Trends Mol Med 21 : 673 ~ 686
Escola JM / 1998 / Selective enrichment of tetraspan proteins on the internal vesicles of mul-tivesicular endosomes and on exosomes secreted by human B-lymphocytes / J Biol
Gnecchi M / 2005 / Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells / Nat Med 11 : 367 ~ 368
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