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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 35 - 42 (8page)
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This study aimed to investigate the effects of probiotic fermentation by comparing the skin antioxidant and anti-inflammatory properties of non-fermented (ARE) and fermented (ARE-F) hot water extracts of Agastache rugosa leaves. ARE-F was obtained via ARE fermentation using Lactobacillus rhamnosus HK-9. In vitro, anti-inflammatory properties were evaluated by analyzing the levels of nitric oxide (NO), reactive oxygen species (ROS), and inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated HaCaT keratinocytes. In vitro antiradical activity was measured using 2,2-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Attenuation of LPS-stimulated NO (p < 0.01), ROS (p < 0.001) and iNOS (p < 0.05) levels by ARE-F was significantly stronger than that by ARE in HaCaT keratinocytes. However, no differences were observed between the DPPH radical scavenging activities of ARE and ARE-F. ARE-F possesses enhanced skin antioxidant and anti-inflammatory properties, suggesting that probiotic bacterial fermentation can be considered an effective tool for augmenting some pharmacological properties of A. rugosa leaves. In brief, the skin antioxidant and anti-inflammatory potentials of A. rugosa leaf extract are augmented by the fermentation with L. rhamnosus HK-9, a probiotic bacterium.
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참고문헌 (21)
참고문헌 신청
Antonopoulou I / 2016 / Enzymatic synthesis of bioactive compounds with high potential for cosmeceutical application / Appl. Microbiol. Biotechnol 100 : 6519 ~ 6543
Bradford MM / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 72 :
Desta KT / 2016 / The polyphenolic profiles and antioxidant effects of Agastache rugosa Kuntze (Banga) flower, leaf, stem and root / Biomed. Chromatogr 30 : 225 ~ 231
Elahi MM / 2009 / Oxidative stress as a mediator of cardiovascular disease / Oxid. Med. Cell. Longev 2 : 259 ~ 269
Ga Yeon Chae / 2011 / The Comparative Evaluation of Fermented and Non-fermented Soybean Extract on Antioxidation and Whitening / 한국독성학회지 27 (4) : 205 ~ 209
Bradford MM / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 72 :
Desta KT / 2016 / The polyphenolic profiles and antioxidant effects of Agastache rugosa Kuntze (Banga) flower, leaf, stem and root / Biomed. Chromatogr 30 : 225 ~ 231
Elahi MM / 2009 / Oxidative stress as a mediator of cardiovascular disease / Oxid. Med. Cell. Longev 2 : 259 ~ 269
Ga Yeon Chae / 2011 / The Comparative Evaluation of Fermented and Non-fermented Soybean Extract on Antioxidation and Whitening / 한국독성학회지 27 (4) : 205 ~ 209
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