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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제9호
- 발행연도
- 2019.1
- 수록면
- 1,361 - 1,368 (8page)
이용수
이 논문의 연구 히스토리 (3)
2019
Co-immunomodulatory Effects of Polysaccharide Extracted from Codium fragile with Red Ginseng Extract in Immune-suppressed Mice
김지은
웰니스바이오산업학과
2019.01
학위논문
Immune Enhancement Effects of Codium fragile Anionic Macromolecules Combined with Red Ginseng Extract in Immune-Suppressed Mice
김지은
,
Chaiwat Monmai
,
박우정
Journal of Microbiology and Biotechnology
2019.01
학술저널
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초록· 키워드
오류제보하기
Codium fragile is an edible seaweed in Asian countries that has been used as a thrombolytic, anticoagulant, antioxidant, anti-inflammatory, and immune-stimulatory agent. Ginseng has also been known to maintain immune homeostasis and to regulate the immune system via enhancing resistance to diseases and microorganisms. In this study, anionic macromolecules extracted from C. fragile (CFAM) were orally administered with red ginseng extract (100 mg/kg body weight) to cyclophosphamide-induced immunosuppressed male BALB/c mice to investigate the immune-enhancing cooperative effect of Codium fragile and red ginseng. Our results showed that supplementing CFAM with red ginseng extract significantly increased spleen index, T- and B-cell proliferation, NK cell activity, and splenic lymphocyte immuneassociated gene expression compared to those with red ginseng alone, even though a high concentration of CFAM with red ginseng decreased immune biomarkers. These results suggest that CFAM can be used as a co-stimulant to enhance health and immunity in immunosuppressed conditions.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Hirayama D / 2017 / The phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis / Int. J. Mol. Sci 19:92~105
Balogh P / 2004 / Immunoarchitecture of distinct reticular fibroblastic domains in the white pulp of mouse spleen / J. Histochem. Cytochem 52:1287~1298
Nolte MA / 2002 / The strict regulation of lymphocyte migration to splenic white pulp does not involve common homing receptors / Immunology 106:299~307
Lori A / 2017 / The spleen : a hub connecting nervous and immune systems in cardiovascular a nd m etab olic d iseases / Int. J. Mol. Sci 18:1216
Mebius RE / 2005 / Structure and function of the spleen / Nat. Rev. Immunol 5:606~616
Balogh P / 2004 / Immunoarchitecture of distinct reticular fibroblastic domains in the white pulp of mouse spleen / J. Histochem. Cytochem 52:1287~1298
Nolte MA / 2002 / The strict regulation of lymphocyte migration to splenic white pulp does not involve common homing receptors / Immunology 106:299~307
Lori A / 2017 / The spleen : a hub connecting nervous and immune systems in cardiovascular a nd m etab olic d iseases / Int. J. Mol. Sci 18:1216
Mebius RE / 2005 / Structure and function of the spleen / Nat. Rev. Immunol 5:606~616
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