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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제10호
- 발행연도
- 2018.1
- 수록면
- 1,626 - 1,634 (9page)
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초록· 키워드
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Ginseng (the root of Panax ginseng Meyer) fermented by Lactobacillus plantarum has been found to attenuate allergic responses in in vitro and in vivo experimental models. Ginseng has been reported to also possess various biological functions including anti-inflammatory activity. The present study was aimed at comparing the anti-allergic effect of ginseng and fermented ginseng extracts on IgE-mediated passive cutaneous anaphylaxis in vitro in a murine cell line and in vivo in mice. Fermented ginseng extract (FPG) showed higher inhibitory effect against in vitro and in vivo allergic responses when compared with ginseng extract (PG). The secretion of β-hexosaminidase and interleukin (IL)-4 from the IgE-DNP-stimulated RBH-2H3 mast cells were significantly (p < 0.05) inhibited by FPG treatment, and this effect was concentration-dependent. Further, MKK4 activation and subsequent JNK phosphorylation were attenuated by FPG treatment. The inhibitory effect of FPG on the in vitro allergic response was verified in vivo against IgE-DNP–induced passive cutaneous anaphylaxis in a mouse model. These data indicated that the fermentation of ginseng with L. plantarum enhanced its anti-allergic effects both in vitro and in vivo. We predict that compositional changes in the ginsenosides caused by the fermentation may contribute to the change in the anti-allergic effects of ginseng. The results of our study highlight the potential of the use of FPG as a potential anti-allergic agent.
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참고문헌 (9)
참고문헌 신청
전재인 / 2015 / Anti-inflammatory Effect of Alloferon on Ovalbumin-induced Asthma / Immune Network 15(6):304~312
Trinh, Hien-Trung / 2010 / Antiallergic Effects of Fermented Ixeris sonchifolia and Its Constituents in Mice / Journal of Microbiology and Biotechnology 20(1):217~223
백인호 / 2013 / The world ginseng market and the ginseng (Korea) / Journal of Ginseng Research 37(1):1~7
김대용 / 2015 / 20(S)-Protopanaxatriol inhibits release of inflammatory mediators in immunoglobulin E-mediated mast cell activation / Journal of Ginseng Research 39(3):189~198
Chi-Yeon Lim / 2015 / Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice / Journal of Ginseng Research 39(1):38~45
Trinh, Hien-Trung / 2010 / Antiallergic Effects of Fermented Ixeris sonchifolia and Its Constituents in Mice / Journal of Microbiology and Biotechnology 20(1):217~223
백인호 / 2013 / The world ginseng market and the ginseng (Korea) / Journal of Ginseng Research 37(1):1~7
김대용 / 2015 / 20(S)-Protopanaxatriol inhibits release of inflammatory mediators in immunoglobulin E-mediated mast cell activation / Journal of Ginseng Research 39(3):189~198
Chi-Yeon Lim / 2015 / Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice / Journal of Ginseng Research 39(1):38~45
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