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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 10 - 19 (10page)
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초록· 키워드
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Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. The AD pathophysiology entails chronic inflammation involving innate immune cells including microglia, astrocytes, and other peripheral blood cells. Inflammatory mediators such as cytokines and complements are also linked to AD pathogenesis. Despite increasing evidence supporting the association between abnormal inflammation and AD, no well-established inflammatory biomarkers are currently available for AD. Since many reports have shown that abnormal inflammation precedes the outbreak of the disease, non-invasive and readily available peripheral inflammatory biomarkers should be considered as possible biomarkers for early diagnosis of AD. In this minireview, we introduce the peripheral biomarker candidates related to abnormal inflammation in AD and discuss their possible molecular mechanisms. Furthermore, we also summarize the current state of inflammatory biomarker research in clinical practice and molecular diagnostics. We believe this review will provide new insights into biomarker candidates for the early diagnosis of AD with systemic relevance to inflammation during AD pathogenesis.
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참고문헌 (123)
참고문헌 신청
Heneka MT / 2015 / Neuroinflammation in Alzheimer's disease / Lancet Neurol 14:388~405
Han SH / 2016 / Amyloid beta-interacting partners in Alzheimer's disease : From accomplices to possible therapeutic targets / Prog Neurobiol 137:17~38
Hansen DV / 2018 / Microglia in Alzheimer's disease / J Cell Biol 217:459~472
Cagnin A / 2001 / In-vivo measurement of activated microglia in dementia / Lancet 358:461~467
Baik SH / 2019 / A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease / Cell Metab 30:493~507 e496
Han SH / 2016 / Amyloid beta-interacting partners in Alzheimer's disease : From accomplices to possible therapeutic targets / Prog Neurobiol 137:17~38
Hansen DV / 2018 / Microglia in Alzheimer's disease / J Cell Biol 217:459~472
Cagnin A / 2001 / In-vivo measurement of activated microglia in dementia / Lancet 358:461~467
Baik SH / 2019 / A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease / Cell Metab 30:493~507 e496
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