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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 127 - 133 (7page)
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초록· 키워드
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Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, antiinflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects.
Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-a/interferon-g-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation.
Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis factor-a and interleukin-1b. G-Rc also markedly suppressed the activation of TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells.
Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling.
Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-a/interferon-g-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation.
Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis factor-a and interleukin-1b. G-Rc also markedly suppressed the activation of TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells.
Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (28)
참고문헌 신청
[학술지(정기간행물)] - 임소연 / 2014 / Role of vascular smooth muscle cell in the inflammation of atherosclerosis / BMB Reports 47 (1) : 1 ~ 7
[학술지(정기간행물)] - Ohno S / 2005 / Role of tumor-associated macrophages(TAM)in advanced gastric carcinoma : the impact on FasL-mediated counterattack / Anticancer Res 25 : 463 ~ 470
[학술지(정기간행물)] - 우연덕 / 2014 / The Roles of Innate Lymphoid Cells in the Development of Asthma / Immune Network 14 (4) : 171 ~ 181
[학술지(정기간행물)] - 김기혜 / 2014 / Characterization of Proinflammatory Responses and Innate Signaling Activation in Macrophages Infected with Mycobacterium scrofulaceum / Immune Network 14 (6) : 307 ~ 320
[학술지(정기간행물)] - 이지선 / 2014 / Immunostimulating activity of maysin isolated from corn silk in murine RAW 264.7 macrophages / BMB Reports 47 (7) : 382 ~ 387
[학술지(정기간행물)] - Ohno S / 2005 / Role of tumor-associated macrophages(TAM)in advanced gastric carcinoma : the impact on FasL-mediated counterattack / Anticancer Res 25 : 463 ~ 470
[학술지(정기간행물)] - 우연덕 / 2014 / The Roles of Innate Lymphoid Cells in the Development of Asthma / Immune Network 14 (4) : 171 ~ 181
[학술지(정기간행물)] - 김기혜 / 2014 / Characterization of Proinflammatory Responses and Innate Signaling Activation in Macrophages Infected with Mycobacterium scrofulaceum / Immune Network 14 (6) : 307 ~ 320
[학술지(정기간행물)] - 이지선 / 2014 / Immunostimulating activity of maysin isolated from corn silk in murine RAW 264.7 macrophages / BMB Reports 47 (7) : 382 ~ 387
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UCI(KEPA) : I410-ECN-0101-2018-524-001598774