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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 61 - 68 (8page)
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초록· 키워드
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Background: Korean Red Ginseng (KRG) is a representative traditional herbal medicine with many different pharmacological properties including anticancer, anti-atherosclerosis, anti-diabetes, and antiinflammatory activities. Only a few studies have explored the molecular mechanism of KRG-mediated anti-inflammatory activity.
Methods: We investigated the anti-inflammatory mechanisms of the protopanaxadiol saponin fraction (PPD-SF) of KRG using in vitro and in vivo inflammatory models.
Results: PPD-SF dose-dependently diminished the release of inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α, and prostaglandin E₂], and downregulated the mRNA expression of their corresponding genes (inducible NO synthase, tumor necrosis factor-α, and cyclooxygenase-2), without altering cell viability. The PPD-SF-mediated suppression of these events appeared to be regulated by a blockade of p38, c-Jun N-terminal kinase (JNK), and TANK (TRAF family member-associated NF-kappa-B activator)-binding kinase 1 (TBK1), which are linked to the activation of activating transcription factor 2 (ATF2) and interferon regulatory transcription factor 3 (IRF3). Moreover, this fraction also ameliorated HCl/ethanol/-induced gastritis via suppression of phospho-JNK2 levels.
Conclusion: These results strongly suggest that the anti-inflammatory action of PPD-SF could be mediated by a reduction in the activation of p38-, JNK2-, and TANK-binding-kinase-1-linked pathways and their corresponding transcription factors (ATF2 and IRF3).
Methods: We investigated the anti-inflammatory mechanisms of the protopanaxadiol saponin fraction (PPD-SF) of KRG using in vitro and in vivo inflammatory models.
Results: PPD-SF dose-dependently diminished the release of inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α, and prostaglandin E₂], and downregulated the mRNA expression of their corresponding genes (inducible NO synthase, tumor necrosis factor-α, and cyclooxygenase-2), without altering cell viability. The PPD-SF-mediated suppression of these events appeared to be regulated by a blockade of p38, c-Jun N-terminal kinase (JNK), and TANK (TRAF family member-associated NF-kappa-B activator)-binding kinase 1 (TBK1), which are linked to the activation of activating transcription factor 2 (ATF2) and interferon regulatory transcription factor 3 (IRF3). Moreover, this fraction also ameliorated HCl/ethanol/-induced gastritis via suppression of phospho-JNK2 levels.
Conclusion: These results strongly suggest that the anti-inflammatory action of PPD-SF could be mediated by a reduction in the activation of p38-, JNK2-, and TANK-binding-kinase-1-linked pathways and their corresponding transcription factors (ATF2 and IRF3).
목차
abstract
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (40)
참고문헌 신청
1. [학술지(정기간행물)] - Sodenkamp J / 2011 / gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis / Eur J Cell Biol 90 : 505 ~ 514
2. [학술지(정기간행물)] - Roberts-Thomson IC / 2011 / Cells, cytokines and inflammatory bowel disease: a clinical perspective / Expert Rev Gastroenterol Hepatol 703 (16) : 703 ~ 716
3. [학술지(정기간행물)] - Ribeiro-Gomes FL / 2006 / Neutrophils, apoptosis and phagocytic clearance: an innate sequence of cellular responses regulating intramacrophagic parasite infections / Parasitology 132 (Suppl) : S61 ~ S68
4. [학술지(정기간행물)] - Yu T / 2012 / The pivotal role of TBK1 in inflammatory responses mediated by macrophages / Mediators Inflamm 2012 : 979105 ~
5. [학술지(정기간행물)] - Byeon SE / 2012 / The role of Src kinase in macrophage-mediated inflammatory responses / Mediators Inflamm 2012 : 512926 ~
2. [학술지(정기간행물)] - Roberts-Thomson IC / 2011 / Cells, cytokines and inflammatory bowel disease: a clinical perspective / Expert Rev Gastroenterol Hepatol 703 (16) : 703 ~ 716
3. [학술지(정기간행물)] - Ribeiro-Gomes FL / 2006 / Neutrophils, apoptosis and phagocytic clearance: an innate sequence of cellular responses regulating intramacrophagic parasite infections / Parasitology 132 (Suppl) : S61 ~ S68
4. [학술지(정기간행물)] - Yu T / 2012 / The pivotal role of TBK1 in inflammatory responses mediated by macrophages / Mediators Inflamm 2012 : 979105 ~
5. [학술지(정기간행물)] - Byeon SE / 2012 / The role of Src kinase in macrophage-mediated inflammatory responses / Mediators Inflamm 2012 : 512926 ~
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UCI(KEPA) : I410-ECN-0101-2018-524-001597575