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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국자료분석학회 Journal of The Korean Data Analysis Society Journal of The Korean Data Analysis Society 제20권 제4호
- 발행연도
- 2018.1
- 수록면
- 1,633 - 1,643 (11page)
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Permutation test has been in common use to get a statistical significance of an association measure when genomic association study is conducted. Its process involves repeated randomizing of the relationships between phenotype and genotype parts of the data as well as the calculation of the testing measure to form a null distribution point from each of the repetition. To compensate for the multiple comparison effect, which can result in overly optimistic p-values, the null distribution should be constructed by the maximum values among all the SNP combinations from each iteration. With increasing number of SNPs, especially when studying higher order gene-gene interactions, the amount of computation may soon become formidable. Possibility of dealing with reduced number of SNPs while producing the comparable result has been investigated in this paper. We found that, down to about 5% of the data considered, the estimated null distribution, verified by p-values were comparable to the one with original set of data.
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참고문헌 (21)
참고문헌 신청
Carrillo, H. / 2014 / Probabilistic performance evaluation for multiclass classification using the posterior balanced accuracy / Robot2013: First Iberian Robotics Conference, Advances in Intelligent Systems and Computing 252:347~361
Carvajal-Rodriguez, A. / 2018 / Myriads: P-value-based multiple testing correction / Bioinformatics 34(6):1043~1045
조장식 / 2012 / Multiple Comparisons for a Bivariate Exponential Populations under Random Censorship / Journal of The Korean Data Analysis Society 14(2):587~595
Dong, C. / 2008 / Exploration of gene-gene interaction effects using entropy-based methods / European Journal of Human Genetics 16:229~235
Heskes, T. / 2014 / A fast algorithm for determining bounds and accurate approximate p-values of the rank product statistics for replicate experiments / BMC Bioinformatics 15:367
Carvajal-Rodriguez, A. / 2018 / Myriads: P-value-based multiple testing correction / Bioinformatics 34(6):1043~1045
조장식 / 2012 / Multiple Comparisons for a Bivariate Exponential Populations under Random Censorship / Journal of The Korean Data Analysis Society 14(2):587~595
Dong, C. / 2008 / Exploration of gene-gene interaction effects using entropy-based methods / European Journal of Human Genetics 16:229~235
Heskes, T. / 2014 / A fast algorithm for determining bounds and accurate approximate p-values of the rank product statistics for replicate experiments / BMC Bioinformatics 15:367
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