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This study was carried out to investigate the protective effect of crude saponin from Platycodon grandiflorum on Clinical chemical parameters in male rats acutely exposed to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD). Crude saponin was prepared from Korean Platycodon grandiflorum with Diaion HP-20 adsorption chromatography after extraction of 80% ethanol at 75℃. The crude saponin was confirmed by thin layer chrmatography. When compared with ginseng saponins, the crude saponin had both a few number of saponins and a broad distribution. Forty male rats (200±20 g) were divided into 4 groups. Normal control (NC) group received vehicle and saline; TCDD-treated (TT) group received TCDD (40 μg/ kg, single dose) intraperitoneally; Platycodon grandiflorum saponin (PG5 and PG10) groups received crude saponin 5 mg/ kg and 10 mg/kg (p.o), respectively, for 2 weeks before 1 week of TCDD-exposure. Increase of body weight was retarded greatly by TCDD-exposure. Body weight of animals in TT group was significantly decrease after 2 days of TCDDexposure. However, body weights of animals in PG groups increased through the experimental perimental period, although the increasing rate was slower than that of NC group. Increases in contents of blood glucose, total cholesterol and triglyceride (TG) and activities of amylase, lipase, AST, ALT and LDH by toxic action of TCDD were significantly attenuated by crude saponin from Platycodon grandiflorum (P<0.05). In conclusion, these results suggest that crude saponin prepared from Korean Platycodon grandiflorum might be a member of useful protective agents against TCDD, which is one of the environmental hormones.
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REFERENCES
참고문헌 (26)
참고문헌 신청
Bombick DW / 1984 / TCDD(2, 3, 7, 8-tetrachlorodibenzo-p-dioxin)causes reduction in the low density lipoprotein*LDL)receptor activities in the hepatic plasma membrane of the guinea pig and rat / Biochemical and Biophysical Research Communications 118:548~554
Brewster DW / 1989 / Differential effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipose tissue tissue lipoprotein lipase activity in the guinea pig, rat, hamster, rabbit and mink / Comparative Biochemistry and Physiology. Part C. Comparative Pharmacology 93:49~53
최철웅 / 2002 / 일차배양 간세포에서 t-Buty lhydroperoxide에 의해 유발된 산화적 스트레스에 대한 길경 열수 추출물의 보호효과 / 약 학 회 지 46(6):466~471
Choi CY / 2001 / Aqueous extract isolated from Platycodon grandiforum elicits release of nitric oxide and tumor necrosis factor-a from murine macrophages / International Immunopharmacology 1:1141~1151
Choi CY / 2001 / Agumentation of macrophage functions by an aqueous extract isolated from Platycodon grandiflorum / Cancer Lett 166:17~25
Brewster DW / 1989 / Differential effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipose tissue tissue lipoprotein lipase activity in the guinea pig, rat, hamster, rabbit and mink / Comparative Biochemistry and Physiology. Part C. Comparative Pharmacology 93:49~53
최철웅 / 2002 / 일차배양 간세포에서 t-Buty lhydroperoxide에 의해 유발된 산화적 스트레스에 대한 길경 열수 추출물의 보호효과 / 약 학 회 지 46(6):466~471
Choi CY / 2001 / Aqueous extract isolated from Platycodon grandiforum elicits release of nitric oxide and tumor necrosis factor-a from murine macrophages / International Immunopharmacology 1:1141~1151
Choi CY / 2001 / Agumentation of macrophage functions by an aqueous extract isolated from Platycodon grandiflorum / Cancer Lett 166:17~25
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UCI(KEPA) : I410-ECN-0101-2020-510-000849697