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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 371 - 379 (9page)
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초록· 키워드
오류제보하기
Mitochondrial dysfunction contributes to the pathogenesis and prognosis of many common disorders, including neurodegeneration, stroke, myocardial infarction, tumor, and metabolic diseases. Ginsenosides, the major bioactive constituents of Panax ginseng (P. ginseng), have been reported to play beneficial roles in the molecular pathophysiology of these diseases by targeting mitochondrial dysfunction. In this review, we first introduce the types of ginsenosides and basic mitochondrial functions. Then, recent findings are summarized on different ginsenosides targeting mitochondria and their key signaling pathways for the treatment of multiple diseases, including neurological disorders, cancer, heart disease, hyperglycemia, and inflammation are summarized. This review may explain the common targets of ginsenosides against multiple diseases and provide new insights into the underlying mechanisms, facilitating research on the clinical application of P. ginseng.
목차
ABSTRACT
1. Introduction
2. Ginsenosides
3. Mitochondrial dysfunction
4. Ginsenosides target mitochondria, treating different diseases
5. Conclusion and perspective
References
참고문헌 (96)
참고문헌 신청
Qi HY / 2018 / Cellular stress response mechanisms as therapeutic targets of ginsenosides / Medicinal Research Reviews 38:625~654
Zheng Q / 2017 / Ginsenoside Rb1 for myocardial ischemia/reperfusion injury : preclinical evidence and possible mechanisms / Oxidative Medicine and Cellular Longevity (2017):1~14
Chaoming Wang / 2020 / Advances in the chemistry, pharmacological diversity, and metabolism of 20(R)-ginseng saponins / Journal of Ginseng Research 44(1):14~23
Boyman L / 2020 / Regulation of mitochondrial ATP production : Ca(2þ)signaling and quality control / Trends in Molecular Medicine 26:21~39
Bock FJ / 2020 / Mitochondria as multifaceted regulators of cell death / Nature Reviews Molecular Cell Biology 21:85~100
Zheng Q / 2017 / Ginsenoside Rb1 for myocardial ischemia/reperfusion injury : preclinical evidence and possible mechanisms / Oxidative Medicine and Cellular Longevity (2017):1~14
Chaoming Wang / 2020 / Advances in the chemistry, pharmacological diversity, and metabolism of 20(R)-ginseng saponins / Journal of Ginseng Research 44(1):14~23
Boyman L / 2020 / Regulation of mitochondrial ATP production : Ca(2þ)signaling and quality control / Trends in Molecular Medicine 26:21~39
Bock FJ / 2020 / Mitochondria as multifaceted regulators of cell death / Nature Reviews Molecular Cell Biology 21:85~100
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인삼의 열처리 과정 중 생성되는 3종의 수산화진세노사이드에 대한 연구
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Possibility as role of ginseng and ginsenosides on inhibiting the heart disease of COVID-19: A systematic review
Journal of Ginseng Research
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Pharmacological and medical applications of Panax ginseng and ginsenosides : a review for use in cardiovascular diseases
Journal of Ginseng Research
2018 .06
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Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles
Journal of Ginseng Research
2022 .01
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Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases
Journal of Ginseng Research
2017 .10
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Mitochondrial targeted strategies and their application for cancer and other diseases treatment
Journal of Pharmaceutical Investigation
2020 .01
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Mitochondrial Dysfunction as a Cause of Neurological Diseases
International Neurourology Journal
2019 .01
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Target engagement of ginsenosides in mild cognitive impairment using mass spectrometry-based drug affinity responsive target stability
Journal of Ginseng Research
2022 .11
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Non-clinical pharmacokinetic behavior of ginsenosides
Journal of Ginseng Research
2019 .06
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Pharmacological potential of ginseng and its major component ginsenosides
Journal of Ginseng Research
2021 .03
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Roles of ginsenosides in sepsis
Journal of Ginseng Research
2023 .01
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Stem-leaves of Panax as a rich and sustainable source of less-polar ginsenosides: comparison of ginsenosides from Panax ginseng, American ginseng and Panax notoginseng prepared by heating and acid treatment
Journal of Ginseng Research
2021 .01
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Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions
Journal of Ginseng Research
2018 .06
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Influence of organic acids and heat treatment on ginsenoside conversion
Journal of Ginseng Research
2018 .10
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Methods on improvements of the poor oral bioavailability of ginsenosides: Pre-processing, structural modification, drug combination, and micro- or nano- delivery system
Journal of Ginseng Research
2023 .11
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Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases
Journal of Ginseng Research
2020 .01
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Variations in Ginsenosides of Raw Ginseng According to Heating Temperature and Time
Journal of Pharmacopuncture
2020 .01
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Inhibition of L-type Ca2+ current by ginsenoside Rd in rat ventricular myocytes
Journal of Ginseng Research
2015 .04
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Modification of ginsenoside composition in red ginseng (Panax ginseng) by ultrasonication
Journal of Ginseng Research
2016 .07
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Synthesis of ginsenoside Rb₁-imprinted magnetic polymer nanoparticles for the extraction and cellular delivery of therapeutic ginsenosides
Journal of Ginseng Research
2022 .09
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