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A lot of research about applications of natural extracts to both food and medicine is in progress. In this paper, we tested the applicability of Rubus crataegifolius leaf extract in functional materials including its anti-inflammatory effects. We investigated the effects of Rubus crataegifolius leaf extract on the LPS-induced production of inflammatory cytokines and mediators in RAW264.7 macrophage cell line. The protein expression of COX-2, iNOS, IL- 4, TNF-α, and IFN-γ, phosphorylation of MAPKs (ERK, JNK, p38) and the activation of NF-κB with Rubus crataegifolius leaf extract were assayed in LPS-stimulated RAW264.7 cells. Pre-treatment with Rubus crataegifolius leaf extract significantly inhibited the protein expression of iNOS and COX-2 in a dose-dependent item and the secretion of inflammatory cytokines such as IL-4, TNF-α, and IFN-γ. Rubus crataegifolius leaf extract significantly reduced the phosphorylation of MAPKs. The NF-κB was strongly suppressed by extracts. Moreover, the pathological phenotypes of contact dermatitis such as erythema, edema, and scabs were significantly decreased in Rubus crataegifolius leaf extract-treated mice. These results indicated that Rubus crataegifolius leaf extract have an antiinflammatory effect, and that this might be used as a supplement for the functional materials.
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참고문헌 (33)
참고문헌 신청
배인순 / 2012 / 황백 열수추출물의 기능성 화장품 천연소재로서의 활용 시험 / 대한미용학회지 8(1):1~8
Ban HJ / 2013 / A study on the cosmeceutical ingredient of the methanol extract of Acanthopanax sessiliflorus Seeman / J. Kor. Soc. Beauty Cultural Arts 2:36~42
Berridge MV / 1993 / Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): Subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction / Arch. Biochem. Biophys 303:474~482
Bobinaitė R / 2012 / Variation of total phenolics, anthocyanins, ellagic acid and radical scavenging capacity in various raspberry (Rubus spp.) cultivars / Food Chem 132:1495~1501
Chen W / 2001 / Role of p38MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes / Oncogene 20:3921~3926
Ban HJ / 2013 / A study on the cosmeceutical ingredient of the methanol extract of Acanthopanax sessiliflorus Seeman / J. Kor. Soc. Beauty Cultural Arts 2:36~42
Berridge MV / 1993 / Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): Subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction / Arch. Biochem. Biophys 303:474~482
Bobinaitė R / 2012 / Variation of total phenolics, anthocyanins, ellagic acid and radical scavenging capacity in various raspberry (Rubus spp.) cultivars / Food Chem 132:1495~1501
Chen W / 2001 / Role of p38MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes / Oncogene 20:3921~3926
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