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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 347 - 352 (6page)
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초록· 키워드
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Background: Panax ginseng (PG) has a long history of use in Asian medicine because of its multiple pharmacological activities. It has been considered that PG in a type of white ginseng may induce undesirable thermogenic effects, but not in a type of red ginseng. However, there is a lack of evidence about the correlation between ginsenoside and thermogenesis.
Methods: We investigated the effects of PG with different ginsenoside compositions on body temperature, blood pressure, and thermogenesis-related factors in rats.
Results: With increasing steaming time (0 h, 3 h, 6 h, and 9 h), the production of protopanaxadiol ginsenosides increased, whereas protopanaxatriol ginsenosides decreased in white ginseng. In both shortand long-term studies, administration of four ginseng extracts prepared at different steaming times did not induce significant changes in body temperature (skin, tail, and rectum) and blood pressure of rats compared to saline control. In addition, there were no significant differences in the molecular markers related to thermogenesis (p > 0.05), mRNA expressions of peroxisome proliferator-activated receptorgamma coactivator-1a and uncoupling protein 1 in brown adipose tissue, as well as the serum levels of interleukin-6, inducible nitric oxide synthase, and nitrite among the treatment groups.
Conclusion: These observations indicate that the potential undesirable effects of PG on body temperature could not be explained by the difference in ginsenoside composition.
Methods: We investigated the effects of PG with different ginsenoside compositions on body temperature, blood pressure, and thermogenesis-related factors in rats.
Results: With increasing steaming time (0 h, 3 h, 6 h, and 9 h), the production of protopanaxadiol ginsenosides increased, whereas protopanaxatriol ginsenosides decreased in white ginseng. In both shortand long-term studies, administration of four ginseng extracts prepared at different steaming times did not induce significant changes in body temperature (skin, tail, and rectum) and blood pressure of rats compared to saline control. In addition, there were no significant differences in the molecular markers related to thermogenesis (p > 0.05), mRNA expressions of peroxisome proliferator-activated receptorgamma coactivator-1a and uncoupling protein 1 in brown adipose tissue, as well as the serum levels of interleukin-6, inducible nitric oxide synthase, and nitrite among the treatment groups.
Conclusion: These observations indicate that the potential undesirable effects of PG on body temperature could not be explained by the difference in ginsenoside composition.
목차
ABSTRACT
1. 서론
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (19)
참고문헌 신청
[학술지(정기간행물)] - Leung KW / 2010 / Pharmacology of ginsenosides : a literature review / Chin Med 5 : 20 ~
[학술지(정기간행물)] - Park EY / 2014 / Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters / Am J Chin Med 42 : 173 ~ 187
[학술지(정기간행물)] - Hong BN / 2015 / The effects of Panax ginseng and Panax quinquefolius on thermoregulation in animal models / Evid Based Complement Alternat Med 2015 : 1 ~ 8
[학술지(정기간행물)] - Wang L / 2000 / Effect of ginseng saponins on cold tolerance in young and elderly rats / Planta Med 66 : 144 ~ 147
[학술지(정기간행물)] - Qi LW / 2010 / American ginseng : potential structureefunction relationship in cancer chemoprevention / Biochem Pharmacol 80 : 947 ~ 954
[학술지(정기간행물)] - Park EY / 2014 / Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters / Am J Chin Med 42 : 173 ~ 187
[학술지(정기간행물)] - Hong BN / 2015 / The effects of Panax ginseng and Panax quinquefolius on thermoregulation in animal models / Evid Based Complement Alternat Med 2015 : 1 ~ 8
[학술지(정기간행물)] - Wang L / 2000 / Effect of ginseng saponins on cold tolerance in young and elderly rats / Planta Med 66 : 144 ~ 147
[학술지(정기간행물)] - Qi LW / 2010 / American ginseng : potential structureefunction relationship in cancer chemoprevention / Biochem Pharmacol 80 : 947 ~ 954
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UCI(KEPA) : I410-ECN-0101-2018-524-001599059